Ten year public health impact of 13-valent pneumococcal conjugate vaccination in infants: A modelling analysis
Autor: | Ray Farkouh, Shreeya Patel, Matt Wasserman, Betsy Hilton, Ruth Chapman, Kelly Sutton, Desmond Dillon-Murphy |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Pediatrics Pneumococcal disease 030231 tropical medicine complex mixtures Pneumococcal Infections Pneumococcal conjugate vaccine Herd immunity Pneumococcal Vaccines 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Child Vaccines Conjugate Modelling analysis General Veterinary General Immunology and Microbiology business.industry Public health Vaccination Pneumococcal conjugate vaccination Public Health Environmental and Occupational Health Infant Pneumonia Pneumococcal medicine.disease Infectious Diseases Child Preschool Pneumococcal pneumonia Molecular Medicine Public Health business medicine.drug |
Zdroj: | Vaccine. 38:7138-7145 |
ISSN: | 0264-410X |
DOI: | 10.1016/j.vaccine.2020.08.068 |
Popis: | Pneumococcal disease is a substantial contributor to illness and death in young children globally. The introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in 2000 had a significant impact in preventing pneumococcal disease in both vaccinated children and unvaccinated individuals (through herd effect). A higher valent PCV13 replaced PCV7 in late 2009. This analysis was undertaken to assess how many cases and deaths have been averted over the last decade since PCV13 introduction. A model estimated the number of infants vaccinated annually with PCV13, as well as the number of cases and deaths of invasive pneumococcal disease, pneumococcal pneumonia, and acute otitis media cases averted. PCV13 vaccination was estimated to have prevented 175.2 million cases of all pneumococcal diseases and 624,904 deaths globally between 2010 and 2019. These results demonstrate the substantial public health impact of PCV13 and highlight the importance of increasing the global reach of PCV programs. |
Databáze: | OpenAIRE |
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