Serum insulin is associated with right ventricle function parameters and lung volumes in subjects free of cardiovascular disease
Autor: | Ricarda von Krüchten, Susanne Rospleszcz, Christopher L. Schlett, Corinna Storz, Blerim Mujaj, Wolfgang Rathmann, Fabian Bamberg, Roberto Lorbeer, Charlotte Kulka, Stefan Karrasch, Annette Peters, Esther Askani |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Population 030209 endocrinology & metabolism Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Germany Internal medicine Diabetes mellitus medicine Humans Insulin Lung volumes Risk factor education Lung Aged education.field_of_study Ejection fraction business.industry Organ Size General Medicine Stroke volume Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Cardiovascular Diseases Ventricle 030220 oncology & carcinogenesis Heart Function Tests Ventricular Function Right Female Lung Volume Measurements business |
Zdroj: | Eur. J. Endocrinol. 184, 289-298 (2021) |
ISSN: | 1479-683X 0804-4643 |
Popis: | Background Diabetes mellitus is an established risk factor for cardiovascular diseases. Even impaired levels of glucose and insulin might harm organ function prior to diabetes onset. Whether serum glucose or insulin plays a direct role in cardiac dysfunction or lung volume reduction remains unclear. The aim was to investigate the relationship between glucose and insulin with the right ventricle and lung volumes within KORA-MRI FF4 study. Methods From the KORA-MRI FF4 cohort study 337 subjects (mean age 55.7 ± 9.1 years; 43% women) underwent a whole-body 3T MRI scan. Cardiac parameters derived from a cine-steady-state free precession sequence using cvi42. MRI-based lung volumes derived semi-automatically using an in-house algorithm. Fasting serum glucose, fasting insulin levels, and HOMA index were calculated in all study subjects. Linear regression analyses were performed to assess the relationships between glucose and insulin levels with right ventricle volumes and lung volumes adjusted for age, sex, BMI, and cardiovascular risk factors. Results In univariate and multivariate-adjusted models, high serum insulin was inversely associated with end-diastolic volume (β = −12.43, P < 0.001), end-systolic volume (β = −7.12, P < 0.001), stroke volume (β = −5.32, P < 0.001), but not with ejection fraction. The association remained significant after additional adjustment for lung volumes. Similarly, serum insulin was inversely associated with lung volume (β = −0.15, P = 0.04). Sensitivity analysis confirmed results after excluding subjects with known diabetes. Conclusions Serum insulin was inversely associated with right ventricle function and lung volumes in subjects from the general population free of cardiovascular disease, suggesting that increased insulin levels may contribute to subclinical cardiopulmonary circulation impairment. |
Databáze: | OpenAIRE |
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