The association between pre-operative sepsis and 30-day mortality in hip fracture patients-A cohort study

Autor:	N. E. Pedersen, C. Ø. Andersen, S. S. Mørch, Christian S. Meyhoff, S. Tantholdt-Hansen, J. O. Jarløv, C. L. Duus, John Asger Petersen
Rok vydání:	2018
Předmět:	Male medicine.medical_specialty Denmark Vital signs law.invention Sepsis Cohort Studies 03 medical and health sciences 0302 clinical medicine Postoperative Complications law Risk Factors Internal medicine medicine Humans 030212 general & internal medicine Aged Retrospective Studies Aged 80 and over Hip fracture business.industry Hip Fractures General Medicine Length of Stay medicine.disease Intensive care unit Pre operative Systemic inflammatory response syndrome Anesthesiology and Pain Medicine 30 day mortality Preoperative Period Female business 030217 neurology & neurosurgery Cohort study
Zdroj:	Acta anaesthesiologica Scandinavica. 62(9)
ISSN:	1399-6576
Popis:	BACKGROUND Post-operative sepsis considerably increases mortality, but the extent of pre-operative sepsis in hip fracture patients and its consequences are sparsely elucidated. The aim of this study was to assess the association between pre-operative sepsis and 30-day mortality after hip fracture surgery. METHODS We conducted a retrospective analysis of data collected among 1894 patients who underwent hip fracture surgery in the Capital Region of Denmark in 2014 (NCT03201679). Data on vital signs, cultures and laboratory data were obtained. Sepsis was defined as a positive culture of any kind and presence of systemic inflammatory response syndrome within 24 hours and was assessed within 72 hours before surgery and 30 days post-operatively. Primary outcome was 30-day mortality. Secondary outcomes included length of hospital stay and admission to intensive care unit. RESULTS A total of 144 (7.6%) of the hip fracture patients met the criteria for pre-operative sepsis. The 30-day mortality was 13.9% in patients with pre-operative sepsis as compared to 9.0% in those without (OR 1.69, 95% CI [1.00; 2.85], P = .08). Patients with pre-operative sepsis had longer hospital stays (median 10 days vs 9 days, mean difference 2.1 [SD 9.4] days, P = .03), and higher frequency of ICU admission (11.1% vs 2.7%, OR 4.15, 95% CI [2.19; 7.87], P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2865c4a2c4c9f91578e6048277e3628c https://pubmed.ncbi.nlm.nih.gov/29797710 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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