Expression of Myxovirus Resistance A (MxA) Is Associated with Tumor-Infiltrating Lymphocytes in Human Epidermal Growth Factor Receptor 2 (HER2)–Positive Breast Cancers
| Autor: | Cheong-Soo Hwang, Chang Hun Lee, Hee Jin Lee, Jee Yeon Kim, Jung Hee Lee, Do Youn Park, Ahrong Kim, Gi Young Huh, Sangjeong Ahn, Gyungyub Gong, So Jeong Lee, Young-Keum Kim, Nari Shin, Dong Hoon Shin, Mi Young Sol, Hyun Jung Lee, Kyung Un Choi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Myxovirus Resistance Proteins 0301 basic medicine Cancer Research Receptor ErbB-2 Lymphovascular invasion H&E stain Gene Expression Breast Neoplasms Tumor-infiltrating lymphocytes Metastasis 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Breast cancer Interferon medicine Humans skin and connective tissue diseases Neoplasm Staging Tissue microarray business.industry Middle Aged Ductal carcinoma Prognosis medicine.disease Immunohistochemistry 030104 developmental biology Oncology Tissue Array Analysis Lymphatic Metastasis 030220 oncology & carcinogenesis Immunology Cancer research Original Article Female Neoplasm Grading business Biomarkers medicine.drug |
| Zdroj: | Cancer Research and Treatment : Official Journal of Korean Cancer Association |
| ISSN: | 2005-9256 1598-2998 |
| DOI: | 10.4143/crt.2016.098 |
| Popis: | Purpose The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been determined in breast cancers. Interferons can affect T-cell activity through direct and indirect mechanisms. Myxovirus resistance A (MxA) is an excellent marker of interferon activity. Here,we evaluated TILs and MxA expression in human epidermal growth factor receptor 2 (HER2)–positive breast cancers. Materials and Methods Ninety cases of hormone receptor (HR)+/HER2+ tumors and 78 cases of HR–/HER2+ tumors were included. The TILs level was assessed using hematoxylin and eosin–stained full face sections, and MxA expressionwas evaluated by immunohistochemistrywith a tissue microarray. Results MxA protein expression was significantly higher in tumors with high histologic grade (p=0.023) and high levels of TILs (p=0.002). High levels of TILs were correlated with high histological grade (p=0.001), negative lymphovascular invasion (p=0.007), negative lymph node metastasis (p=0.007), absence of HR expression (p < 0.001), abundant tertiary lymphoid structures (TLSs) around ductal carcinoma in situ (p=0.018), and abundant TLSs around the invasive component (p < 0.001). High levels of TILs were also associated with improved disease-free survival, particularly in HR–/HER2+ breast cancers. However, MxA was not a prognostic factor. Conclusion High expression of MxA in tumor cells was associated with high levels of TILs in HER2-positive breast cancers. Additionally, a high level of TILs was a prognostic factor for breast cancer, whereas the level of MxA expression had no prognostic value. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|