CDKN2BAS polymorphisms are associated with coronary heart disease risk a Han Chinese population
| Autor: | Jingjie Li, Shudan Liao, Qingbin Zhao, Dandan Liu, Tianbo Jin, Huiyi Wei, Mengdan Yan, Xiyang Zhang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Coronary Disease 030204 cardiovascular system & hematology single nucleotide polymorphisms Research Paper: Gerotarget (Focus on Aging) 0302 clinical medicine Gene Frequency Risk Factors Odds Ratio Traditional medicine Gerotarget Homozygote CDKN2BAS Middle Aged 3. Good health Phenotype Oncology Female RNA Long Noncoding case-control China Heterozygote medicine.medical_specialty Single-nucleotide polymorphism Polymorphism Single Nucleotide Risk Assessment 03 medical and health sciences Sex Factors Asian People Internal medicine Genetic model medicine Humans Genetic Predisposition to Disease coronary heart disease Allele Genetic Association Studies Chi-Square Distribution business.industry Haplotype Odds ratio Protective Factors Confidence interval Logistic Models 030104 developmental biology Haplotypes Case-Control Studies business |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.12575 |
| Popis: | // Qingbin Zhao 1 , Shudan Liao 2 , Huiyi Wei 1 , Dandan Liu 3 , Jingjie Li 4,5 , Xiyang Zhang 5 , Mengdan Yan 4,5 and Tianbo Jin 4,5 1 Department of Geratology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China 2 Department of Cardiology, Xi’an Center Hospital, Xi’an, Shaanxi, China 3 Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China 4 Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi’an, Shaanxi, China 5 Xi’an Tiangen Precision Medical Institute, Xi’an, Shaanxi, China Correspondence to: Qingbin Zhao, email: // Keywords : coronary heart disease; single nucleotide polymorphisms; CDKN2BAS; case-control,Gerotarget Received : September 01, 2016 Accepted : October 05, 2016 Published : October 11, 2016 Abstract The goal of our study was to determine whether CDKN2BAS polymorphisms are associated with coronary heart disease (CHD) risk in a Han Chinese population. Eight SNPs were genotyped in 676 men and 465 women. We used χ 2 tests and genetic model analyses to evaluate associations between the SNPs and CHD risk. We found that rs10757274 was associated with an increased risk of CHD in both men (allele G: Odds ratio [OR] = 1.30, 95% confidence interval [CI]: 1.05-1.61, P = 0.018; codominant model: P = 0.042; recessive model: OR = 1.70, 95% CI: 1.10-2.62, P = 0.016; log-additive model: OR = 1.34, 95% CI: 1.05-1.71, P = 0.019) and women (dominant model: OR = 2.26, 95% CI: 1.28-3.99, P = 0.004). In addition, rs7865618 was associated with an 8.10-fold increased risk of CHD in women under a recessive model (OR = 8.10, 95% CI: 1.74-37.68, P = 0.006). Interestingly, the haplotype AA (rs10757274 and rs1333042) of CDKN2BAS was associated with decreased the risk of CHD in men (OR = 0.72, 95% CI: 0.55 - 0.95, P = 0.022). |
| Databáze: | OpenAIRE |
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