A Non-obese, Treatment-Naive Japanese Diabetic Patient With Elevated Insulin Clearance and Hyperglycemia Under Enhanced Insulin Sensitivity and Increased Insulin Secretion: Elevated Insulin Clearance as Type 2 Japanese Diabetes Mellitus (T2JDM)
| Autor: | Noboru Kurinami, Kunio Hieshima, Katsunori Jinnouchi, Seigo Sugiyama, Hideaki Jinnouchi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Endogeny Type 2 diabetes 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Insulin resistance insulin resistance c peptide immunoreactivity Internal medicine Diabetes mellitus Internal Medicine hyperinsulinemic euglycemic clamp examination medicine Insulin-degrading enzyme insulin degrading enzyme insulin sensitivity business.industry nonobese Insulin Metabolic disorder Endocrinology/Diabetes/Metabolism General Engineering medicine.disease insulin clearance Peripheral Endocrinology diabetes mellitus Preventive Medicine type 2 diabetes hyperglycemia business 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.14354 |
| Popis: | Diabetes mellitus is a heterogeneous and complex metabolic disorder characterized by hyperglycemia secondary to either resistance to insulin actions on the liver and peripheral tissues, insufficient insulin secretion from pancreatic β-cells, or both. An integrated balance between blood insulin levels and whole-body insulin sensitivity could theoretically provide the clinical effectiveness of insulin action. Peripheral blood insulin concentrations might be determined by the capacity of endogenous pancreatic β-cell insulin secretion and the degree of the whole body insulin clearance. Here, we report a non-obese normoinsulinemic Japanese diabetic patient with elevated insulin clearance assessed by a hyperinsulinemic-euglycemic clamp examination and increased insulin secretion measured by daily urinary excretion of C-peptide immunoreactivity. We propose this unique pathogenic condition of diabetes with normoinsulinemia and elevated insulin clearance as “type 2 Japanese diabetes mellitus (T2JDM).” |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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