Human albumin and starch administration in critically ill patients: A prospective randomized clinical trial
| Autor: | Jeroen Oude Nijhuis, Arend J J Woittiez, Thiemo F Veneman |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Oncotic pressure
medicine.medical_specialty Critical Illness medicine.medical_treatment Hypovolemia Plasma Substitutes Sodium Chloride Hydroxyethyl starch law.invention Hydroxyethyl Starch Derivatives Osmotic Pressure law Intensive care medicine Humans Hospital Mortality Prospective Studies Hypoalbuminemia Infusions Intravenous Saline Serum Albumin Aged Netherlands business.industry Hemodynamics Albumin General Medicine Water-Electrolyte Balance medicine.disease Survival Analysis Intensive care unit Surgery Intensive Care Units Outcome and Process Assessment Health Care Anesthesia business Fluid replacement medicine.drug |
| Zdroj: | Wiener Klinische Wochenschrift. 116:305-309 |
| ISSN: | 1613-7671 0043-5325 |
| DOI: | 10.1007/bf03040900 |
| Popis: | To determine whether intravenous infusion of either human albumin or hydroxyethylstarch (HES) in hypo-albuminemic critically ill may lead to an increase in colloid osmotic pressure and to a better clinical outcome, i.e. lower mortality and fewer complications, compared to fluid replacement with normal saline Prospective, randomized controlled clinical trial during 72 hours in 61 consecutively admitted severely ill patients. Randomisation took place by sealed envelope, kept outside of the hospital. Intensive care unit of the Twenteborg Hospital, Almelo, The Netherlands. Sixty-three severely ill, hypo-albuminemic patients were selected; 27 patients had severe sepsis and 36 were post-surgical patients with SIRS. Two patients died shortly after randomization, 15 patients received human albumin, 15 HES 500 and 15 HES 1000 ml, and 16 saline. The patients were randomized to receive 300 ml human albumin (20%) per day, or 1000 ml normal saline per day, or 500 ml or 1000 ml HES per day, all for 72 hours. The primary outcome was plasma colloid osmotic pressure (COP). Secondary end-points were fluid balance and the development of pulmonary edema. Administration of human albumin was effective in raising COP (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink