Does Inflammation Predispose to Recurrent Vascular Events after Recent Transient Ischaemic Attack and Minor Stroke? the North West of England Transient Ischaemic Attack and Minor Stroke (NORTHSTAR) Study
| Autor: | Sharon Hulme, Andy Vail, J Staniland, Francine Jury, Nancy J. Rothwell, Philippa Tyrrell, Rachel Georgiou, William E R Ollier, Antony Payton, Johann R. Selvarajah, Craig J. Smith, Karen J. Illingworth, Stephen J. Hopkins, Charles Sherrington |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Genetic Markers Male medicine.medical_specialty Genotype Single-nucleotide polymorphism Inflammation Minisatellite Repeats Fibrinogen Polymorphism Single Nucleotide Cohort Studies Pathogenesis Gene Frequency Recurrence Internal medicine Confidence Intervals Odds Ratio medicine Humans Stroke Aged Aged 80 and over Immunoassay medicine.diagnostic_test business.industry Incidence (epidemiology) Odds ratio Middle Aged medicine.disease Surgery Cerebrovascular Disorders Logistic Models Treatment Outcome England Socioeconomic Factors Neurology Ischemic Attack Transient Case-Control Studies Sample Size Erythrocyte sedimentation rate Cardiology Female medicine.symptom business medicine.drug |
| Zdroj: | International Journal of Stroke. 6:187-194 |
| ISSN: | 1747-4949 1747-4930 |
| DOI: | 10.1111/j.1747-4949.2010.00561.x |
| Popis: | Background and hypothesis Inflammation is implicated in the pathogenesis and outcome of ischaemic injury. Poststroke inflammation is associated with outcome but it remains unclear whether such inflammation precedes or results from ischaemic injury. We hypothesised that inflammatory markers are associated with an increased risk of recurrent vascular events soon after transient ischaemic attack and minor stroke. Methods This was a multicentre, prospective, nested case–control study. Plasma concentrations of C-reactive protein, interleukin-6, interleukin-1-receptor antagonist and fibrinogen, leucocyte counts, erythrocyte sedimentation rate and inflammatory gene allele frequencies were analysed in 711 patients with recent transient ischaemic attack or minor stroke. Cases were defined by the incidence of one or more recurrent vascular events during the three-month follow-up. Association of inflammatory markers with case-status was determined using conditional logistic regression. Results Plasma concentrations of C-reactive protein, interleukin-1-receptor antagonist and interleukin-6 were not associated with case-status. In secondary analyses, only erythrocyte sedimentation rate was significantly associated with case-status (odds ratio 1·39, 95% confidence interval 1·03–1·85; P=0·03), but this effect did not persist after adjustment for smoking and past history of transient ischaemic attack or stroke. Single nucleotide polymorphisms in four inflammatory genes (interleukin-6, fibrinogen, P-selectin and vascular cell adhesion molecule-1) were nominally associated with case-status. Conclusions Circulating inflammatory markers were not associated with recurrent vascular events. Nominally significant associations between genetic markers and case-status will require replication. These data provide little evidence for an inflammatory state predisposing to stroke and other vascular events in a susceptible population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text