Defective growth hormone secretion in primary microcephaly
| Autor: | C, Dacou-Voutetakis, T, Karpathios, N, Logothetis, M, Constantinidis, N, Matsaniotis, E, Michalopoulou |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.medical_specialty Primary microcephaly Hypoglycemia Iodine Radioisotopes Plasma growth hormone Internal medicine medicine Humans Insulin Oral glucose Child Growth Disorders Pituitary hypofunction Clinical Trials as Topic business.industry medicine.disease Growth hormone secretion Circadian Rhythm Glucose Endocrinology Growth Hormone Pituitary Gland Pediatrics Perinatology and Child Health Microcephaly Female Abnormality business GH Deficiency |
| Zdroj: | The Journal of Pediatrics. 85:498-502 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(74)80452-x |
| Popis: | The 24 hr variations of plasma growth hormone (GH) andlor GH secretion provoked by oral glucose load or by insulin-induced hypoglycemia were studied in five microcephalic children. Low levels of GH and, especially, complete lack of secretory episodes were detected in three of the five children, two of whom were brothers. GH deficiency may constitute the principal or a contributing factor of impaired growth in some microcephalic children. A possible association between the cerebral abnormality and the pituitary hypofunction is suggested. An analogy is made between the present cases and the neuroendocrine complexes reported as Kallmann's and de Morsier's syndromes, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|