High-level resistance to aminoglycoside, vancomycin, and linezolid in enterococci strains
| Autor: | Gulcin Baldir, Asuman Inan, Metin Kucukercan, Derya Ozturk Engin, Seniha Senbayrak Akcay, Seyfi Özyürek, Sebahat Aksaray |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Enterococcus avium
vancomycin lcsh:QR1-502 Pharmaceutical Science linezolid Enterococcus spp. vancomycin linezolid aminoglycoside resistance Enterococcus faecalis lcsh:Microbiology Microbiology Enterococcus spp vankomisin linezolid aminoglikozid direnç resistance chemistry.chemical_compound Health Care Sciences and Services medicine Pharmacology (medical) Sağlık Bilimleri ve Hizmetleri biology Teicoplanin Enterococcus spp biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Enterococcus durans Complementary and alternative medicine chemistry Streptomycin Linezolid Vancomycin aminoglycoside medicine.drug Enterococcus faecium |
| Zdroj: | Volume: 3, Issue: 03 100-103 Journal of Microbiology and Infectious Diseases Journal of Microbiology and Infectious Diseases, Vol 3, Iss 3, Pp 100-103 (2013) |
| ISSN: | 2146-3158 2146-9369 |
| Popis: | Amaç: Bu çalışmada, enterokok suşlarının antibiyotik duyarlılık oranlarının saptanması, vankomisin duyarlı enterokok (VSE) ve vankomisin dirençli enterokok (VRE) suşlarındaki yüksek düzey aminoglikozid direncinin karşılaştırılması amaçlandı. Yöntemler: Haydarpaşa Numune Eğitim ve Araştırma Hastanesi kliniklerinden gönderilen örneklerden, laboratuvarımızda izole edilen 100 adet VRE, 100 adet VSE suşu çalışma kapsamına alındı.Bulgular: VRE suşlarının tümü Enterococcus faecium olarak tanımlanmış olup, VSE suşlarının ise %53’ü Enterococcus faecalis, %42’si E. faecium, %3’ü Enterococcus durans, %2’si Enterococcus avium olarak tespit edildi. VRE suşlarının tümünde yüksek düzey vankomisin direnci (MİK, >256 µg/ml) belirlendi, teikoplanin MİK değerleri incelendiğinde beş suş orta duyarlı (MİK, 16µg/ml), 95 suş dirençli (MİK, >32 µg/ml) olarak saptandı. VRE suşlarından biri linezolid dirençli (MİK, 12 µg/ml), biri ise orta duyarlı (MİK, 4 µg/ml) olarak saptandı, diğer suşlar duyarlı (MİK Objective: This study sought to identify antibiotic susceptibility rates of enterococcal strains, and to compare the high-level resistance to aminoglycosides (HLAR) in vancomycin-sensitive enterococcal species (VSE) and vancomycin-resistant enterococcal species (VRE). Materials and Methods: The study included 100 VRE and 100 VSE strains recovered from the samples sent to laboratory from various departments of Haydarpasa Numune Training and Research Hospital. Results: All VRE strains were defined as Enterococcus faecium, although of the VSE strains, 53% were identified to be as Enterococcus faecalis, 42% E. faecium, 3% Enterococcus durans, and 2% Enterococcus avium. High-level resistance to vancomycin (MIC, >256 µg/ml) was determined in all VRE strains and when analyzing MIC values for teicoplanin, five strains were found to be moderately susceptible (MIC, 16 µg/ml) and 95 strains were resistant (MIC, >32 µg/ml). Of the VRE strains, one was linezolid-resistant (MIC, 12 µg/ml) and the other was intermediately susceptible (MIC, 4 µg/ml) and remainders were evaluated to be susceptible (MIC |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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