The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives
| Autor: | Constantinos Tsioufis, V. Katsi, Ioannis Skiadas, M. Poulakis, Dimitris Syrseloudis, Kyriakos Dimitriadis, Costas Mihas, Skevos Sideris, S. Lalos, C. Stefanadis, Elli Stefanadi, Stella-Maria Kyvelou |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Context (language use) Essential hypertension Vascular Stiffness Internal medicine Internal Medicine Humans Medicine Pulse wave velocity Inflammation Adiponectin biology business.industry C-reactive protein Middle Aged medicine.disease Uric Acid C-Reactive Protein Cross-Sectional Studies Blood pressure Endocrinology Hypertension biology.protein Arterial stiffness Regression Analysis Female business |
| Zdroj: | Journal of Human Hypertension. 25:554-559 |
| ISSN: | 1476-5527 0950-9240 |
| DOI: | 10.1038/jhh.2010.98 |
| Popis: | The data regarding the role of serum uric acid (SUA) along with subclinical inflammation in the context of hypertensive vascular damage are rather scarce and controversial. Towards this end, we assess the links between SUA, high-sensitivity CRP (hs-CRP), adiponectin and carotid to femoral pulse wave velocity (c-f PWV) in 292 subjects with never-treated stage I-II essential hypertension. On the basis of the median SUA levels (0.31 mmol l(-1)), the study population was divided into subjects with low (n=149) and high (n=143) SUA values. By multiple regression analysis, it was revealed that SUA was independently associated with log hs-CRP (R(2)=0.098; P=0.02), log adiponectin (R(2)=0.102; P=0.03), waist circumference (R(2)=0.049; P=0.04), 24-h systolic blood pressure (SBP) (R(2)=0.179; P=0.001) and estimated glomerular filtration rate (R(2)=0.156; β (s.e.)=-0.169 (0.023); P=0.02). In addition, c-f PWV was independently associated with age (R(2)=0.116; P |
| Databáze: | OpenAIRE |
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