Consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer: achievements and future directions
| Autor: | Chris E. Forsmark, Stephen J. Pandol |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pancreatic disease Basic science business.industry Gastroenterology medicine.disease Article Pancreatic Neoplasms Natural history Clinical trial Pancreatitis Chronic Diabetes mellitus Pancreatic cancer Acute Disease Diabetes Mellitus medicine Humans Pancreatitis Acute pancreatitis Prospective Studies Intensive care medicine business Early Detection of Cancer |
| Zdroj: | Curr Opin Gastroenterol |
| ISSN: | 1531-7056 0267-1379 |
| Popis: | Purpose of review To answer several important clinical questions, the Consortium for the study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) research consortium has established several ongoing clinical cohort studies focused on pancreatitis in adults and children, pancreatic cancer, and diabetes associated with pancreatic disease. These will provide a unique resource for clinical and basic science research into these hard-to-treat diseases. Recent findings The cause, natural history, and prognosis of acute relapsing and chronic pancreatitis in adults and children are being delineated. The mechanisms of diabetes associated with chronic pancreatitis, acute pancreatitis, and pancreatic cancer are being defined. The ability to predict the presence of early-stage pancreatic cancer, thought the presence of new-onset diabetes, is being explored as a strategy to improve survival. The CPDPC is now also turning to developing clinically useful biomarkers, and initiating clinical trials in these difficult to treat pancreatic diseases. Summary These large prospective patient cohorts, established and followed up by the CPDPC, provide a unique resource to improve the care of patients of all ages with pancreatitis, and to allow earlier diagnosis of pancreatic cancer. |
| Databáze: | OpenAIRE |
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