The LKB1 tumor suppressor kinase in human disease
| Autor: | Tea Vallenius, Lina Udd, Kari Vaahtomeri, Tomi P. Mäkelä, Marianne Tiainen, Pekka Katajisto, Niklas Ekman |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Cancer Research Lung Neoplasms Peutz-Jeghers Syndrome Regulator Peutz–Jeghers syndrome Adenocarcinoma Protein Serine-Threonine Kinases Biology Mice 03 medical and health sciences 0302 clinical medicine Germline mutation AMP-Activated Protein Kinase Kinases Genetics medicine Animals Humans skin and connective tissue diseases Cell Proliferation 030304 developmental biology Serine/threonine-specific protein kinase 0303 health sciences Cyclooxygenase 2 Inhibitors Kinase Cell growth Tumor Suppressor Proteins Cell Polarity Cancer medicine.disease 3. Good health Oncology 030220 oncology & carcinogenesis Immunology Cancer research Signal transduction Protein Kinases Signal Transduction |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1775:63-75 |
| ISSN: | 0304-419X |
| Popis: | Inactivating germline mutations in the LKB1 gene underlie Peutz-Jeghers syndrome characterized by hamartomatous polyps and an elevated risk for cancer. Recent studies suggest the involvement of LKB1 also in more common human disorders including diabetes and in a significant fraction of lung adenocarcinomas. These observations have increased the interest towards signaling pathways of this tumor suppressor kinase. The recent breakthroughs in understanding the molecular functions of the LKB1 indicate its contribution as a regulator of cell polarity, energy metabolism and cell proliferation. Here we review how the substrates and cellular functions of LKB1 may be linked to Peutz-Jeghers syndrome and other diseases, and discuss how some of the molecular changes associated with altered LKB1 signaling might be used in therapeutic approaches. |
| Databáze: | OpenAIRE |
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