Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis
| Autor: | L. A. Cherdantseva, A. M. Anikina, A. V. Troitskii, T. V. Sharkova, A. V. Kovner, V. A. Shkurupy, O. V. Potapova |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Programmed cell death Pathology medicine.medical_specialty 030106 microbiology Apoptosis General Biochemistry Genetics and Molecular Biology BALB/c Mice 03 medical and health sciences Fibrosis hemic and lymphatic diseases medicine Animals Lung Granuloma Mice Inbred BALB C Granuloma Lung Pulmonary interstitium biology business.industry Macrophages General Medicine Fibroblasts biology.organism_classification medicine.disease Immunohistochemistry 030104 developmental biology medicine.anatomical_structure BCG Vaccine business |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 165:48-51 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-4096-8 |
| Popis: | Light microscopy, immunohistochemistry, and morphometric examinations established that cell death in lung granulomas of BCG-infected mice resulted mainly from activation of receptor-mediated apoptosis, which did not prevent the persistence of the causative agent in macrophages of the granulomas and promoted the formation of pronounced fibrosis in granulomas and pulmonary interstitium. |
| Databáze: | OpenAIRE |
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