Breast Cancer Survival in Relation to the Metastatic Tumor Burden in Axillary Lymph Nodes
Autor: | Jana de Boniface, Jan Frisell, Leif Bergkvist, Yvette Andersson, Maria Sylvan |
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Rok vydání: | 2010 |
Předmět: |
Oncology
Cancer Research medicine.medical_specialty Axillary lymph nodes Breast Neoplasms Kaplan-Meier Estimate Disease-Free Survival Metastasis Cohort Studies Breast cancer Internal medicine Humans Medicine Prospective Studies Prospective cohort study Lymph node Survival analysis Neoplasm Staging business.industry Cancer Prognosis medicine.disease Survival Analysis Surgery Treatment Outcome medicine.anatomical_structure Lymphatic Metastasis Axilla Lymph Node Excision Female Lymph Nodes Breast disease business |
Zdroj: | Journal of Clinical Oncology. 28:2868-2873 |
ISSN: | 1527-7755 0732-183X |
Popis: | Purpose The aim of this study was to determine the prognostic significance of lymph node micrometastases in patients with breast cancer. Patients and Methods Between September 2000 and January 2004, 3,369 patients with breast cancer were included in a prospective cohort. According to their lymph node status, they were classified in the following four groups: 2,383 were node negative, 107 had isolated tumor cells, 123 had micrometastases, and 756 had macrometastases. Median follow-up time was 52 months. Kaplan-Meier estimates and the multivariate Cox proportional hazard regression model were used to analyze survival. Results Five-year cause-specific and event-free survival rates were lower for patients with micrometastases (pN1mi) than for node-negative (pN0) patients (94.1% v 96.9% and 79.6% v 87.1%, respectively; P = .020 and P = .032, respectively). There was no significant survival difference between node-negative patients and those with isolated tumor cells. The overall survival of pN1mi and pN0 patients did not differ. Conclusion This study demonstrates a worse prognosis for patients with micrometastases than for node-negative patients. |
Databáze: | OpenAIRE |
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