Perfusion MR imaging for differentiation of benign and malignant meningiomas
| Autor: | Hao Zhang, Tianzhen Shen, Jingtao Miao, Matthijs Oudkerk, Lars A. Rodiger |
|---|---|
| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Pathology Adolescent Malignant meningioma brain Clinical Neurology Contrast Media Brain Edema Perfusion scanning meningioma Magnetic resonance angiography Meningioma 1ST-PASS Meningeal Neoplasms medicine Humans magnetic resonance imaging Radiology Nuclear Medicine and imaging Meningeal Neoplasm PERMEABILITY Neuroradiology Blood Volume perfusion-weighted imaging medicine.diagnostic_test business.industry food and beverages Magnetic resonance imaging Functional Neuroradiology Middle Aged medicine.disease GLIOMAS TUMORS Radiology Nuclear Medicine and imaging Cerebrovascular Circulation VOLUME Female Neurology (clinical) Radiology cerebral neoplasm business Cardiology and Cardiovascular Medicine Perfusion Magnetic Resonance Angiography |
| Zdroj: | Neuroradiology, 50(6), 525-530. SPRINGER Neuroradiology |
| ISSN: | 0028-3940 |
| Popis: | Introduction Our purpose was to determine whether perfusion MR imaging can be used to differentiate benign and malignant meningiomas on the basis of the differences in perfusion of tumor parenchyma and/or peritumoral edema.Methods A total of 33 patients with preoperative meningiomas (25 benign and 8 malignant) underwent conventional and dynamic susceptibility contrast perfusion MR imaging. Maximal relative cerebral blood volume (rCBV) and the corresponding relative mean time to enhance (rMTE) ( relative to the contralateral normal white matter) in both tumor parenchyma and peritumoral edema were measured. The independent samples t-test was used to determine whether there was a statistically significant difference in the mean rCBV and rMTE ratios between benign and malignant meningiomas.Results The mean maximal rCBV values of benign and malignant meningiomas were 7.16 +/- 4.08 (mean +/- SD) and 5.89 +/- 3.86, respectively, in the parenchyma, and 1.05 +/- 0.96 and 3.82 +/- 1.39, respectively, in the peritumoral edema. The mean rMTE values were 1.16 +/- 0.24 and 1.30 +/- 0.32, respectively, in the parenchyma, and 0.91 +/- 0.25 and 1.24 +/- 0.35, respectively, in the peritumoral edema. The differences in rCBV and rMTE values between benign and malignant meningiomas were not statistically significant(P > 0.05) in the parenchyma, but both were statistically significant (P Conclusion Perfusion MR imaging can provide useful information on meningioma vascularity which is not available from conventional MRI. Measurement of maximal rCBV and corresponding rMTE values in the peritumoral edema is useful in the preoperative differentiation between benign and malignant meningiomas. |
| Databáze: | OpenAIRE |
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