Highly Efficient Fluorescent Material Based on Rare-Earth-Modified Polyhydroxyalkanoates
Autor: | Xiao-Ran Jiang, Xu Zhang, Lin-Ping Yu, Daixu Wei, Guo-Qiang Chen, Qiong Wu |
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Rok vydání: | 2019 |
Předmět: |
Photoluminescence
Materials science Polymers and Plastics Biocompatibility Polymers Metal ions in aqueous solution Biocompatible Materials Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Polyhydroxyalkanoates Biomaterials Materials Chemistry Chelation Sulfhydryl Compounds Fluorescent Dyes chemistry.chemical_classification Polymer 021001 nanoscience & nanotechnology Fluorescence Acetylcysteine 0104 chemical sciences chemistry Click chemistry Click Chemistry Metals Rare Earth Halomonas 0210 nano-technology |
Zdroj: | Biomacromolecules. 20:3233-3241 |
ISSN: | 1526-4602 1525-7797 |
Popis: | Fluorescent materials play an important role in biomedical fields. However, the main types of fluorescent materials suffer from several disadvantages especially the biotoxicity, which largely restrict its wider applications in biological fields. In this study, a highly efficient rare-earth-modified fluorescent material was successfully designed and fabricated based on polyhydroxyalkanoates, which are known as biodegradable and biocompatible materials. A new Functional-PHA polymer was microbially synthesized by engineered Halomonas bluephagenesis and was used as a basal matrix to generate the rare-earth-modified PHA. N-Acetyl-l-cysteine-grafted PHA (NAL-grafted-PHA) was first produced via a UV-initiated thiol-ene click reaction and the rare earth metal ions (Eu3+ and Tb3+) were subsequently chelated onto the NAL-grafted-PHA through the coordination effect. The composite material exhibited intense photoluminescence properties under UV laser excitation, indicating the excellent features as fluorescent material. The enhanced hydrophilicity and superior biocompatibility of rare-earth-chelated PHA were confirmed, suggesting its great potential application value in biomedical fields. |
Databáze: | OpenAIRE |
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