Effect of endogenous cortisol levels on natural killer cell activity in healthy humans
| Autor: | Ann Ho, Mary Jeanne Kreek, Gershon Bodner |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Immunology Stimulation Endogeny Adrenocorticotropic hormone Dexamethasone Behavioral Neuroscience Adrenocorticotropic Hormone In vivo Internal medicine medicine Humans Glucocorticoids Metyrapone Endocrine and Autonomic Systems business.industry beta-Endorphin Cytotoxicity Tests Immunologic Stimulation Chemical Killer Cells Natural Endocrinology Dexamethasone suppression test Female business medicine.drug Psychoneuroimmunology |
| Zdroj: | Brain, behavior, and immunity. 12(4) |
| ISSN: | 0889-1591 |
| Popis: | The aim of this study was to examine the effects of increasing and decreasing endogenous cortisol levels on natural killer (NK) cell activity in vivo. Normal healthy volunteers participated in the following studies: baseline (n = 27), metyrapone challenge test (n = 10), dexamethasone suppression test (n = 10), and adrenocorticotropic hormone (ACTH) stimulation test (n = 8). Each subject served as his own control for each study. Each subject was tested for NK activity and plasma cortisol levels at 9 a.m., just before the challenge drug administration, and at 10 a.m., except for the dexamethasone study, in which only the 9 a.m. blood was drawn, 10 h after the dexamethasone administration. On the baseline study day, a significant decrease in plasma cortisol levels was found from 9 to 10 a.m. (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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