Evaluation of the anticoagulant potential of polysaccharide-rich fractions extracted from macroalgae
| Autor: | Thierry Maugard, Stanislas Baudouin, Nicolas Bridiau, Delphine Dufour, Amandine Adrien |
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| Přispěvatelé: | LIttoral ENvironnement et Sociétés - UMRi 7266 (LIENSs), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2017 |
| Předmět: |
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
medicine.drug_class Drug Evaluation Preclinical Fucus vesiculosus Low molecular weight heparin Plant Science Thrombin time Phaeophyta 01 natural sciences Biochemistry Analytical Chemistry Microbiology Polysaccharides Chondrus crispus Himanthalia elongata medicine Humans Food science Blood Coagulation biology medicine.diagnostic_test 010405 organic chemistry Heparin Organic Chemistry Anticoagulants Laminaria digitata biology.organism_classification Seaweed 0104 chemical sciences 010404 medicinal & biomolecular chemistry Anticoagulant Agent Partial Thromboplastin Time Ascophyllum circulatory and respiratory physiology |
| Zdroj: | Natural Product Research Natural Product Research, Taylor & Francis, 2017, ⟨10.1080/14786419.2017.1278595⟩ |
| ISSN: | 1478-6419 1029-2349 |
| DOI: | 10.6084/m9.figshare.4609186.v1 |
| Popis: | The aim of this study was to evaluate the potential anticoagulant activity of sulphated polysaccharide-containing extracts of six french edible marine macroalgae. Aqueous extracts of brown (Himanthalia elongata, Laminaria digitata, Ascophyllum nodosum, Fucus vesiculosus), green (Ulva lactuca) and red (Chondrus crispus) macroalgae were prepared and their biochemical properties were determined, including major biomolecules, sulphate and ash contents. The anticoagulant activity of each extract was investigated using different scales from the specific antithrombin-dependent pathway (anti-Xa and anti-IIa) to the intrinsic and/or common (Activated Partial Thromboplastin Time, APTT), extrinsic (Prothrombin Time, PT) or common (Thrombin Time, TT) anticoagulant pathways, and compared with those of commercial anticoagulants, heparin and Lovenox®. Laminaria digitata, Fucus vesiculosus and Chondrus crispus extracts showed a significant APTT anticoagulant capacity, only 5-fold lower than that of Lovenox®, which is a pure low molecular weight heparin used as an anticoagulant agent to prevent pulmonary embolism in patients undergoing surgery. |
| Databáze: | OpenAIRE |
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