Altered activity of plasma hemopexin in patients with minimal change disease in relapse
| Autor: | Theo Borghuis, Joanna A.E. van Wijk, Catharina M. L. van Dael, Jola J. Kapojos, Winston W. Bakker, Jeroen Nauta, Leonie J. W. M. Pierik |
|---|---|
| Přispěvatelé: | Pediatrics |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Electrophoresis
Male medicine.medical_specialty CHANGE NEPHROTIC SYNDROME hemopexin Adolescent Glomerulonephritis Membranoproliferative Arbitrary unit Blotting Western PATHOGENESIS HEME-BINDING PROTEINS Nephropathy Recurrence Internal medicine medicine Humans Minimal change disease Child Proteinuria Glomerulosclerosis Focal Segmental business.industry nephrotic syndrome Nephrosis Lipoid Remission Induction Glomerulonephritis IGA Hemopexin medicine.disease POLYMORPHISM Titer Endocrinology minimal change disease Nephrology Case-Control Studies Pediatrics Perinatology and Child Health INTERLEUKIN-6 RESPONSE ELEMENT Prednisolone RAT Female medicine.symptom proteinuria business Nephrotic syndrome Peptide Hydrolases medicine.drug |
| Zdroj: | Pediatric Nephrology, 20(10), 1410-1415. SPRINGER Pediatric Nephrology, 20(10), 1410-1415. Springer-Verlag |
| ISSN: | 0931-041X |
| Popis: | Since an active isoform of plasma hemopexin (Hx) has been proposed to be a potential effector molecule in minimal change disease (MCD), we tested plasma and urine samples from subjects with MCD in relapse (n =18) or in remission (n =23) (after treatment with prednisolone) for presence or activity of Hx. For comparison, plasma or urine from proteinuric subjects with focal and segmental glomerulosclerosis (FSGS, n =11), membranoproliferative glomerulonephritis (MPGN, n =9), IgA nephropathy (n =5) or healthy control donors (n =10), were incorporated into the study. Electrophoresis and Western blotting methods were used for evaluation of the Hx status, whereas protease activity of Hx was tested upon kidney tissue in vitro according to standard methods. The results show (1) a decreased mean titer of plasma Hx exclusively in MCD relapse subjects as compared with MCD in remission (0.21 +/- 0.14 mg/ml vs 0.44 +/- 0.06 mg/ml; p |
| Databáze: | OpenAIRE |
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