Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism
| Autor: | Hirohisa Kato, Shigeto Yamada, Hironori Komori, Etsuo Ohtaki, Toyojiro Matsuishi, Yushiro Yamashita |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Metabolite Biopterin Personality Assessment chemistry.chemical_compound Cerebrospinal fluid Oral administration Biogenic amine Internal medicine Developmental and Educational Psychology medicine Humans Autistic Disorder Child chemistry.chemical_classification Neurotransmitter Agents medicine.diagnostic_test Lumbar puncture Homovanillic acid Homovanillic Acid Hydroxyindoleacetic Acid medicine.disease Treatment Outcome Endocrinology chemistry Child Preschool Autism Female Psychology |
| Zdroj: | Journal of Autism and Developmental Disorders. 25:183-193 |
| ISSN: | 1573-3432 0162-3257 |
| DOI: | 10.1007/bf02178503 |
| Popis: | Treatment with 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) has been suggested to improve autistic behavior. Cerebrospinal fluid (CSF) levels of total biopterin, oxidized and reduced forms of biopterin, homovanillic acid, and 5-hydroxyindoleacetic acid were measured in 14 autistic children and 18 controls to clarify the mechanism of action of R-THBP. The 14 autistic children received R- THBP orally at 1 mg/kg per day; 7 children showed clinical improvement (responders) and the other 7 patients did not (nonresponders). There were no significant differences between responders, nonresponders, and controls in the CSF levels of the metabolites before R- THBP administration. When lumbar puncture was repeated in 6 autistic children in the 24th week of R-THBP therapy, there was no significant change in the CSF levels of any metabolites. |
| Databáze: | OpenAIRE |
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