Microvascular invasion and positive HB e antigen are associated with poorer survival after hepatectomy of early hepatocellular carcinoma: A retrospective cohort study
| Autor: | Yun Li, De-Liang Guo, Guo-Liang Qiao, Chang Xu, Qian Zhu, Jie Tang, Rui Duan, Jian Liu |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment 030230 surgery Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Hepatectomy Humans Early Hepatocellular Carcinoma Neoplasm Invasiveness Hepatitis B e Antigens Risk factor Retrospective Studies Prothrombin time Hepatology medicine.diagnostic_test business.industry Liver Neoplasms Retrospective cohort study Middle Aged Stepwise regression Prognosis digestive system diseases HBeAg 030220 oncology & carcinogenesis Microvessels Prothrombin Time Female business Cohort study |
| Zdroj: | Clinics and Research in Hepatology and Gastroenterology. 42:330-338 |
| ISSN: | 2210-7401 |
| Popis: | We aimed to identify the independent predictive factors of microvascular invasion (MVI) for curative resection of HCC and to investigate the impacts of MVI and HBeAg on long-term recurrence and survival after resection.The clinicopathological parameters of 237 patients with HCC with MVI who underwent hepatic resection from April 2005 to November 2010 were investigated. Clinical features and factors associated with the clinical outcomes of 386 patients with HCC without MVI were used for comparison.Multivariate stepwise logistic regression analysis revealed that alpha-fetoprotein level100μg/L, positive HBeAg, and tumour size were independent prognostic factors in patients with HCC with MVI. The overall survival (OS) of patients in the HCC with MVI group was significantly poorer compared with the HCC without MVI group (P0.001). However, patients with HCC without MVI group exhibited a significantly better recurrence-free survival rate (RFS) (P0.001). While the HCC with positive HBeAg group exhibited significantly lower OS compared with the HCC with negative HBeAg group (P=0.007).AFP level100μg/L, positive HBeAg, and tumour size2cm are independent indicators of poorer prognosis for HCC with MVI. The present study confirmed that microvascular invasion itself had a negative impact on patient survival; moreover, HBeAg was an independent risk factor influencing OS, while not RFS of patients with HCC underwent hepatectomy. It is important to predict the presence of MVI before hepatic resection to determine treatment strategies. |
| Databáze: | OpenAIRE |
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