Post-weaning social isolation of rats induces reduction in the gene expression of vascular endothelial growth factor (VEGF) in the hippocampus
| Autor: | Natasa Hlavacova, Daniela Jezova, Igor Riecansky, Magdalena Chmelova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Nitric Oxide Synthase Type III Physiology Biophysics Down-Regulation Weaning Hippocampus chemistry.chemical_compound Downregulation and upregulation Enos Internal medicine Gene expression medicine Hippocampus (mythology) Animals Chronic stress RNA Messenger Fibroblast biology General Medicine biology.organism_classification Rats Vascular endothelial growth factor medicine.anatomical_structure Endocrinology chemistry Social Isolation Female Fibroblast Growth Factor 2 Signal transduction |
| Zdroj: | General physiology and biophysics. 38(4) |
| ISSN: | 0231-5882 |
| Popis: | The role of vascular endothelial growth factor (VEGF) in chronic stress and neurodevelopmental disorders is of growing research interest. Here we show that post-weaning isolation rearing of rats decreased gene expression of VEGF in the hippocampus. Gene expression of VEGF upstream regulator fibroblast growth factor-2 (FGF-2) or its downstream mediator endothelial nitric oxide synthase (eNOS) was unchanged. Other signaling pathways appear to be involved in isolation-induced reduction in VEGF gene expression. Sex differences in VEGF and eNOS gene expression with significantly higher mRNA levels in females than males were revealed. |
| Databáze: | OpenAIRE |
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