Role of the P2X4 receptor in neuropathic pain
| Autor: | Kazuhide Inoue |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Bioinformatics 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Drug Discovery Animals Humans Medicine Receptor Pharmacology Microglia business.industry Chronic pain medicine.disease Spine Disease Models Animal 030104 developmental biology medicine.anatomical_structure ATP Receptors Peripheral nerve injury Neuropathic pain Neuralgia business Receptors Purinergic P2X4 Ionotropic effect |
| Zdroj: | Current Opinion in Pharmacology. 47:33-39 |
| ISSN: | 1471-4892 |
| DOI: | 10.1016/j.coph.2019.02.001 |
| Popis: | Neuropathic pain is the most important type of chronic pain because it is refractory to available medications. Neuropathic pain occurs after peripheral nerve injury (PNI) or nerve damage by various reasons. In recent decades, a growing body of evidence shows that spinal microglia and P2X4 receptor (P2X4R), a subtype of ionotropic ATP receptors, play a principal role in evoking this pain. Understanding the functions of microglial P2X4R in evoking this pain provides potential strategies for developing new treatments for neuropathic pain. |
| Databáze: | OpenAIRE |
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