Isoniazid preventive therapy use among adult people living with HIV in Zimbabwe
| Autor: | Charles Sandy, Shrish Balachandra, Michelle L Pearson, Talent Maphosa, Regis Choto, John H. Rogers, Mayuko Takamiya, Kudawashe Takarinda, Elizabeth Radin, Avi J Hakim, Musuka Godfrey |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Zimbabwe medicine.medical_specialty Human immunodeficiency virus (HIV) Antitubercular Agents HIV Infections Dermatology 030312 virology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine parasitic diseases Isoniazid Medicine Humans Tuberculosis Pharmacology (medical) 030212 general & internal medicine 0303 health sciences business.industry Public Health Environmental and Occupational Health Preventive therapy Infectious Diseases Cross-Sectional Studies Family medicine business medicine.drug |
| Zdroj: | International journal of STDAIDS. 32(11) |
| ISSN: | 1758-1052 |
| Popis: | We assessed the prevalence of isoniazid preventive therapy (IPT) uptake and explored factors associated with IPT non-uptake among people living with HIV (PLHIV) using nationally representative data from the Zimbabwe Population-based HIV Impact Assessment (ZIMPHIA) 2015–2016. This was a cross-sectional study of 3418 PLHIV ZIMPHIA participants eligible for IPT, aged ≥15 years and in HIV care. Logistic regression modeling was performed to assess factors associated with self-reported IPT uptake. All analyses accounted for multistage survey design. IPT uptake among PLHIV was 12.7% (95% confidence interval (CI): 11.4–14.1). After adjusting for sex, age, rural/urban residence, TB screening at the last clinic visit, and hazardous alcohol use, rural residence was the strongest factor associated with IPT non-uptake (adjusted OR (aOR): 2.39, 95% CI: 1.82–3.12). Isoniazid preventive therapy non-uptake having significant associations with no TB screening at the last HIV care (aOR: 2.07, 95% CI: 1.54–2.78) and with hazardous alcohol use only in urban areas (aOR: 10.74, 95% CI: 3.60–32.0) might suggest suboptimal IPT eligibility screening regardless of residence, but more so in rural areas. Self-reported IPT use among PLHIV in Zimbabwe was low, 2 years after beginning national scale-up. This shows the importance of good TB screening procedures for successful IPT implementation. |
| Databáze: | OpenAIRE |
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