Interactions between the growth hormone and cytokines – A review
| Autor: | Roman Janas, Anna Malinowska, Monika Prokop-Piotrkowska, Mieczysław Szalecki |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030209 endocrinology & metabolism Growth hormone Growth hormone deficiency 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine medicine Animals Humans Endocrine system Tumor Necrosis Factor-alpha business.industry Interleukins Interleukin General Medicine Metabolism medicine.disease 030104 developmental biology Endocrinology Growth Hormone Cytokines Tumor necrosis factor alpha business |
| Zdroj: | Advances in Medical Sciences. 63:285-289 |
| ISSN: | 1896-1126 |
| DOI: | 10.1016/j.advms.2018.03.001 |
| Popis: | Numerous reports on the interactions between the immune and endocrine systems, especially growth hormone axis, can be found in the literature. Growth hormone acts mainly indirectly through insulin-like growth factor-1, which stimulates the growth and development processes, metabolism of lipids, proteins, and carbohydrates, and it also has a modulating effect on the cells of the immune system. Several studies have been conducted on the influence of growth hormone therapy on the immunological parameters in children and adults with and without growth hormone deficiency. However, there have been no definite results and some of them have been even contradictory. Some studies have suggested that administration of growth hormone increases the production of tumor necrosis factor and certain pro- and anti-inflammatory cytokines; whereas other studies have demonstrated the lack of correlation between growth hormone and interleukins. The aim of this paper was to evaluate the available literature on the interaction between growth hormone and TNF-α, pro-inflammatory (IL-1β, IL-2, IL-6) and anti-inflammatory (IL-4, IL-10) interleukins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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