Subclinical Peritubular Capillaritis at 3 Months Is Associated With Chronic Rejection at 1 Year
| Autor: | Evelyne Lerut, Dirk Kuypers, Yves Vanrenterghem, Boudewijn Van Damme, Maarten Naesens |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Graft Rejection Male Vasculitis Pathology medicine.medical_specialty Time Factors Kidney Peritubular capillaries Asymptomatic Antibodies Basement Membrane Biopsy medicine Humans Kidney transplantation Aged Subclinical infection Transplantation medicine.diagnostic_test urogenital system business.industry Transplant glomerulopathy Middle Aged medicine.disease Fibrosis Kidney Transplantation Capillaries Kidney Tubules medicine.anatomical_structure Acute Disease Chronic Disease Female medicine.symptom business |
| Zdroj: | Transplantation. 83:1416-1422 |
| ISSN: | 0041-1337 |
| Popis: | Background. Peritubular capillaritis has been associated with chronic rejection, but the characteristics of subclinical lesions in peritubular capillaries are unknown. Methods. Fifty-three renal allograft recipients underwent a protocol biopsy at both 3 and 12 months after transplantation. Subclinical chronic antibody-mediated rejection (CAMR) at 1 year was diagnosed when three or more of five criteria were present: basement membrane multilayering of peritubular capillaries (MLPTC), transplant glomerulopathy, increase in intimal fibrosis between 3 and 12 months, C4d deposition in peritubular capillaries, and the presence of anti-human leukocyte antigen antibodies. Results. Six (11.3%) patients met the criteria of CAMR. MLPTC was the most sensitive (83.3%) and specific (89.1%) histological criterion (P=0.0008). Five patients had peritubular capillaritis at their 3-month biopsy. They all developed MLPTC at 1 year (P |
| Databáze: | OpenAIRE |
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