The dopamine β-hydroxylase inhibitor, nepicastat, suppresses chocolate self-administration and reinstatement of chocolate seeking in rats
Autor: | Paola Maccioni, Giancarlo Colombo, Alessandro Zaru, Gian Luigi Gessa |
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Rok vydání: | 2013 |
Předmět: |
Male
Time Factors media_common.quotation_subject Medicine (miscellaneous) Self Administration Craving Dopamine beta-Hydroxylase Pharmacology Candy Random Allocation chemistry.chemical_compound Dopamine medicine Dopamine β hydroxylase Animals Palatability Rats Wistar media_common Cacao Nutrition and Dietetics Dose-Response Relationship Drug business.industry digestive oral and skin physiology Imidazoles Thiones Appetite Feeding Behavior Rats chemistry Food Nepicastat Conditioning Operant Conditioning Cues medicine.symptom Self-administration business Reinforcement Psychology medicine.drug |
Zdroj: | British Journal of Nutrition. 110:1524-1533 |
ISSN: | 1475-2662 0007-1145 |
Popis: | Craving for chocolate is a common phenomenon, which may evolve to an addictive-like behaviour and contribute to obesity. Nepicastat is a selective dopamine β-hydroxylase (DBH) inhibitor that suppresses cocaine-primed reinstatement of cocaine seeking in rats. We verified whether nepicastat was able to modify the reinforcing and motivational properties of a chocolate solution and to prevent the reinstatement of chocolate seeking in rats. Nepicastat (25, 50 and 100 mg/kg, intraperitoneal) produced a dose-related inhibition of operant self-administration of the chocolate solution in rats under fixed-ratio 10 (FR10) and progressive-ratio schedules of reinforcement, measures of the reinforcing and motivational properties of the chocolate solution, respectively. The effect of nepicastat on the reinstatement of chocolate seeking was studied in rats in which lever-responding had been extinguished by removing the chocolate solution for approximately 8 d. Nepicastat dose-dependently suppressed the reinstatement of lever-responding triggered by a ‘priming’ of the chocolate solution together with cues previously associated with the availability of the reward. In a separate group of food-restricted rats trained to lever-respond for regular food pellets, nepicastat reduced FR10 lever-responding with the same potency as for the chocolate solution. Spontaneous locomotor activity was not modified by nepicastat doses that reduced self-administration of the chocolate solution and regular food pellets and suppressed the reinstatement of chocolate seeking. The results indicate that nepicastat reduces motivation to food consumption sustained by appetite or palatability. Moreover, the results suggest that DBH inhibitors may be a new class of pharmacological agents potentially useful in the prevention of relapse to food seeking in human dieters. |
Databáze: | OpenAIRE |
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