Controversies in the management of parathyroid carcinoma: A case series and review of the literature
| Autor: | Giulia Loi, Francesco Podda, Giuseppe Pisano, Enrico Erdas, Fabio Medas, Pietro Giorgio Calò, Angelo Nicolosi |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Malignancy 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Aged business.industry Neck dissection General Medicine Middle Aged Hyperparathyroidism Primary medicine.disease Surgery Parathyroid Neoplasms Central Lymph Node Dissection Parathyroid carcinoma 030220 oncology & carcinogenesis Hypercalcemia Thyroidectomy Lymph Node Excision Neck Dissection Female 030211 gastroenterology & hepatology Lymph High incidence Neoplasm Recurrence Local business Primary hyperparathyroidism |
| Zdroj: | International Journal of Surgery. 28:S94-S98 |
| ISSN: | 1743-9191 |
| DOI: | 10.1016/j.ijsu.2015.12.040 |
| Popis: | Parathyroid carcinoma is a rare malignancy representing less than 1% of primary hyperparathyroidism cases. Its management is controversial due to lack of large-scale, multicentric studies. We report 8 new cases of parathyroid carcinoma and review the literature. Preoperative diagnosis of carcinoma was possible in 2 (25%) cases. Unclear surgical margins were present in 5 (62.5%) patients; 4 of them underwent subsequent re-exploration and ipsilateral hemithyroidectomy, in one case associated to central lymph node dissection. Recurrent disease is reported in 2 (25%) patients. Considering the high incidence of local recurrence in case of unclear surgical margins, a re-exploration with ipsilateral hemithyroidectomy is indicated in these patients. A neck dissection should be performed only in case of clinically involved lymph nodes, avoiding prophylactic lymphectomy. An aggressive approach is indicated in case of local or distant recurrence to reduce hypercalcemia. |
| Databáze: | OpenAIRE |
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