Hereditary hypotrophic axonopathy with neurofilament deficiency in a mutant strain of the Japanese quail
| Autor: | C. Itakura, M. Mizutani, H. Yamasaki |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty Neurofilament Intermediate Filaments Coturnix Biology Microtubules Pathology and Forensic Medicine Cellular and Molecular Neuroscience Microtubule biology.animal medicine Animals Axon Intermediate filament Bird Diseases Spinal cord biology.organism_classification Axons Quail Microscopy Electron medicine.anatomical_structure nervous system Peripheral nervous system Mutation Neurology (clinical) Nervous System Diseases |
| Zdroj: | Acta Neuropathologica. 82:427-434 |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/bf00293376 |
| Popis: | A primary axonal disease affecting the central and peripheral nervous system was discovered in a new mutant strain of the Japanese quail, named quiver (Quv). Quv showed significantly smaller cross-sectional areas of the cervical spinal cord and the optic and sciatic nerves, when compared with controls by light microscopic morphometry. In the cervical spinal cord, electron microscopic morphometry indicated that myelinated axons in Quv were significantly smaller in size than in controls, though greater in density. The axonal circularity was not significantly different from that of controls. Electron microscopically and immunohistochemically, neurofilaments were not detected in the axons or neuronal cell bodies. Axons in Quv were composed mainly of microtubules, which were increased in number in relation to the axonal size. From these findings, the lesions observed in Quv were regarded as axonal hypotrophy (growth arrest or retardation) due to altered neurofilament expression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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