Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests
| Autor: | Norma Marchetti, Meghan Glibbery, Rahul Chanchlani, M. Constantine Samaan, Olufemi Ajani, Adam Fleming, Alexa Marr |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
myalgia
Pediatrics medicine.medical_specialty Arginine business.industry 030209 endocrinology & metabolism Stimulation Case Report General Medicine Growth hormone medicine.disease Gross hematuria Clonidine Growth hormone deficiency 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis medicine Stimulation tests Medicine medicine.symptom business medicine.drug |
| Zdroj: | Case Reports in Medicine Case Reports in Medicine, Vol 2020 (2020) |
| ISSN: | 1687-9635 1687-9627 |
| Popis: | Growth hormone deficiency (GHD) in children has significant impacts on growth and metabolism. Two-agent GH stimulation tests are commonly used to diagnose GHD, and these tests are generally considered safe. We report the case of a 5-year 5-month-old boy with a history of anaplastic ependymoma who underwent GH stimulation testing for growth deceleration using clonidine and arginine. He developed bilateral calf myalgia and gross hematuria within 24 hours of the tests. Myalgia and hematuria resolved spontaneously. Importantly, the literature review and database searches for hematuria identified 6 cases with clonidine and 20 cases with arginine. This case highlights an unusual combination of adverse reactions to clonidine and arginine in children undergoing GH stimulation testing to assess for GHD. Pediatric endocrinologists need to be aware of the potential for these side effects to allow appropriate management, and further studies are needed to clarify the mechanisms and frequency of these side effects. We recommend that patients and families need to be counselled about hematuria as an association of GH testing with these medications. |
| Databáze: | OpenAIRE |
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