Bioavailability of alpha-linolenic acid from flaxseed diets as a function of the age of the subject
| Autor: | Mirna N. Chahine, Melanie N. Richard, Linda Malcolmson, C M C Dupasquier, Amanda F. Patenaude, Andrea L. Edel, Grant N. Pierce, J.A. Austria, Elena Dibrov, Delfin Rodriguez-Leyva |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Aging Adolescent Linolenic acid Medicine (miscellaneous) Biological Availability Biology Intestinal absorption chemistry.chemical_compound Young Adult Essential fatty acid Double-Blind Method Internal medicine Flax Blood plasma medicine Humans Triglycerides Aged chemistry.chemical_classification Nutrition and Dietetics Triglyceride Cholesterol alpha-Linolenic Acid Middle Aged Eicosapentaenoic acid Dietary Fats Diet Endocrinology chemistry Eicosapentaenoic Acid Intestinal Absorption Seeds Plant Preparations Polyunsaturated fatty acid |
| Zdroj: | European journal of clinical nutrition. 63(9) |
| ISSN: | 1476-5640 |
| Popis: | Dietary flaxseed may have beneficial cardiovascular effects. An aged population has a higher incidence of cardiovascular disease, but they may react differently to flaxseed in the diet.To investigate the response, over a period of 4 weeks, of subjects aged 18-29 or 45-69 years to a diet containing the same amount of alpha-linolenic acid (ALA) (6 g) introduced in the form of ground flaxseed (30 g) or flaxseed oil.All subjects who received flaxseed oil showed a significant increase in plasma ALA and eicosapentaenoic acid (EPA) concentrations over the course of this study. Subjects who received ground flaxseed in the 18-29-year-old group showed a statistically significant increase in their plasma ALA levels, and although there was a trend in the same direction for the 45-69-year-old subjects, this did not achieve statistical significance. The diets induced no major changes in platelet aggregation, plasma total cholesterol, low-density lipoprotein or high-density lipoprotein cholesterol levels in any of the groups. Younger subjects showed a decrease in triglyceride (TG) values compared with older subjects. There were no significant side effects that caused compliancy issues.Subject age does not seem to be a major determining factor in influencing ALA absorption from a flaxseed-supplemented diet nor in the metabolism of ALA to EPA in the groups fed flaxseed oil. Concerns about side effects in older subjects administered a higher fiber load in a flaxseed-supplemented diet are not justified. However, younger but not older subjects showed a beneficial decrease in circulating TGs due to flaxseed supplementation. |
| Databáze: | OpenAIRE |
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