Cardiorespiratory Fitness is Associated with Glycated Hemoglobin and Triglyceride Levels in Severely Obese Men: A Retrospective Clinical Data Analysis
| Autor: | Martin Thurnheer, Britta Wilms, Rahel Keppler, Bernd Schultes, Barbara Ernst, Sebastian M. Schmid |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Physical fitness 030209 endocrinology & metabolism Severity of Illness Index 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Internal Medicine Medicine Humans Obesity Triglycerides Aged Retrospective Studies Glycated Hemoglobin Triglyceride business.industry Insulin Cholesterol HDL Cardiorespiratory fitness General Medicine Cholesterol LDL Middle Aged medicine.disease 030104 developmental biology Cross-Sectional Studies chemistry Cardiorespiratory Fitness Homeostatic model assessment Female Glycated hemoglobin business |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 128(1) |
| ISSN: | 1439-3646 |
| Popis: | Background Even subjects with severe obesity show a wide range of metabolic health states, with some showing marked alterations in glucose and lipid metabolism whereas others do not. In severely obese women, we could recently show that the degree of cardiorespiratory fitness is, independently of body mass and age, associated with several markers of glucose and lipid metabolism. Aims In our retrospective study on a clinical data set, we questioned whether such an association also exists in severely obese men. Methods Cardiorespiratory fitness, i. e. workload (Wpeak) and oxygen uptake (V̇O2,peak) at peak exercise, was assessed by a bicycle spiroergometry in 133 severely obese men (all BMI>35 kg m−2). The following metabolic blood markers were also measured: Fasting serum glucose, insulin, triglycerides (TG), total, low-, high-density cholesterol (Chol, LDL, HDL), uric acid, and whole blood glycated hemoglobin (HbA1c). The Chol/HDL ratio and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) were also calculated. Results Multiple stepwise linear regression models including age, body mass, and smoking status as independent variables revealed that Wpeak and V̇O2,peak, explained 4.5 to 10.7% of variance in HbA1c and TG (all beta Conclusions Similar to previous observations in women, our data indicate that cardiorespiratory fitness assessed by bicycle ergospirometry test is associated with glucose and lipid metabolism in severely obese men. The strength of the found associations suggest a mild to moderate influence of cardiorespiratory fitness on metabolic health in severe obesity. |
| Databáze: | OpenAIRE |
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