Critical review of the publications on the genotoxicology of aluminium salts: 1990–2018
| Autor: | Peter Jenkinson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aluminum sulphate
Health Toxicology and Mutagenesis 010501 environmental sciences Toxicology Bioinformatics medicine.disease_cause 01 natural sciences Oxidative damage 03 medical and health sciences Genetics Animals Humans Medicine Mode of action Genetics (clinical) 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Weight of evidence business.industry Mechanism (biology) Neurodegenerative Diseases Oxidative Stress Review Literature as Topic Salts business Good laboratory practice Genotoxicity Aluminum DNA Damage Mutagens |
| Zdroj: | Mutagenesis. 36:109-127 |
| ISSN: | 1464-3804 0267-8357 |
| Popis: | Since the mid-1970s, there have been many reports that purport to implicate aluminium in the aetiology of neurodegenerative disease. After several decades of research, the role of aluminium in such disease remains controversial and is not the subject of this review. However, if aluminium is implicated in such disease then it follows that there must be a toxicological mechanism or mode of action, and many researchers have investigated various potential mechanisms including the involvement of oxidative damage, cytotoxicity and genotoxicity. This paper reviews many of the publications of studies using various salts of aluminium and various genotoxicity end points, both in vitro and in vivo, with a focus on oxidative damage. The conclusion of this review is that the majority, if not all, of the publications that report positive results have serious technical flaws and/or implausible findings and consequently should contribute little or no weight to a weight of evidence (WoE) argument. There are many high-quality, Good Laboratory Practice (GLP)-compliant genotoxicity studies, that follow relevant OECD test guidelines and the European Chemicals Agency (ECHA) integrated mutagenicity testing strategy, on several salts of aluminium; all demonstrate clear negative results for both in vitro and in vivo genotoxicity. In addition, the claim for an oxidative mode of action for aluminium can be shown to be spurious. This review concludes that there are no reliable studies that demonstrate a potential for genotoxicity, or oxidative mode of action, for aluminium. |
| Databáze: | OpenAIRE |
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