Long-term follow-up and prognostic factors for advanced thymic carcinoma
| Autor: | Sufang Qiu, Hui-qin Chen, Jiezhong Wang, Junxin Wu, Ling-dong Shao, Jinluan Li, Qian-yu Ni, Jianji Pan, Bu-hong Zheng |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty China Time Factors Adolescent Observational Study Gastroenterology Disease-Free Survival Article Young Adult Internal medicine medicine Humans Stage (cooking) Young adult Child Survival rate Thymic carcinoma Aged Neoplasm Staging Retrospective Studies Aged 80 and over Proportional hazards model business.industry Retrospective cohort study General Medicine Thymus Neoplasms Middle Aged medicine.disease Prognosis Combined Modality Therapy Confidence interval Surgery Survival Rate T-stage Female business Follow-Up Studies |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | The aim of this study was to evaluate the long-term survival outcomes in patients with advanced thymic carcinoma and identify prognostic factors influencing the survival. We retrospectively analyzed 90 consecutive patients with pathologically confirmed advanced thymic carcinoma (Masaoka III and IV) in our institute, from December 2000 to 2012. Age, sex, clinical characteristics, laboratory findings, Masaoka and tumor node metastasis staging, pathologic grade, and treatment modalities were analyzed to identify prognostic factors associated with the progress-free survival (PFS) and the overall survival (OS) rates. Statistical analysis was conducted using SPSS, version 19.0 (SPSS, Inc, Chicago, IL). A total of 73 (81.1%) male and 17 (18.9%) female patients participated in the study. The median follow-up time was 75 months (range, 20–158 months). The 5-year PFS and OS rates were 23.6% (95% confidence interval [CI], 14.6%–33.8%) and 35.7% (95% CI, 25.1%–46.4%), respectively. The multivariate Cox regression model analysis showed that factors improving the PFS were the normal lactate dehydrogenase (LDH) level (P |
| Databáze: | OpenAIRE |
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