Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques
| Autor: | R C Nowinski, U R Rapp |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
viruses
Immunology Mice Inbred Strains Chick Embryo Biology Virus Replication Microbiology Defective virus Virus Cell Line BALB/c Mice chemistry.chemical_compound Antigen Idoxuridine Virology Murine leukemia virus Animals Antigens Viral Defective Viruses RNA-Directed DNA Polymerase biology.organism_classification Leukemia Virus Murine Cell Transformation Neoplastic Retroviridae chemistry Viral replication Cell culture Insect Science DNA Research Article |
| Zdroj: | Journal of Virology. 18:411-417 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.18.2.411-417.1976 |
| Popis: | Endogenous ecotropic type C viruses were induced by iodedeoxyuridine from nontransformed and chemically or spontaneously transformed clones of the C3H/10T1/2 cell line. Viruses produced by cells of certain transformed clones were N-tropic and formed large XC plaques. In contrast, viruses produced by nontransformed C3H/10T1/2 cells were not detectable in the XC plaque test. These XC- viruses infected mouse cells with high efficiency, as shown by the induction of murine leukemia virus group-specific antigens in infected cells, but virus production, as determined by DNA polymerase-containing particles, was extremely low. Upon growth in certain mouse cells these replication-deficient, XC(-) viruses converted to type C viruses that were similar in XC assays to N-tropic AKR virus (XC+). |
| Databáze: | OpenAIRE |
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