WT1 expression is inversely correlated with MYCN amplification or expression and associated with poor survival in non‐MYCN‐amplified neuroblastoma

Autor: Dominique Valteau-Couanet, Catherine Huber, Qingyuan Liu, Evelyne Ségal-Bendirdjian, Eric Nguyen, Jean Bénard, Caroline Masserot, Charles-Henry Gattolliat
Přispěvatelé: Signalisation, noyaux et innovations en cancérologie (UMR8126), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy], Institut Gustave Roussy (IGR), Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS), Homéostasie cellulaire et cancer - Reprogrammation des réponses biologiques et thérapies alternatives (U1007), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), Centre National de la Recherche Scientifique (CNRS)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Signalisation, noyaux et innovations en cancérologie ( UMR8126 ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut Gustave Roussy ( IGR ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Gustave Roussy ( IGR ), Mathématiques Appliquées à Paris 5 ( MAP5 - UMR 8145 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National des Sciences Mathématiques et de leurs Interactions-Centre National de la Recherche Scientifique ( CNRS ), Homéostasie cellulaire et cancer - Reprogrammation des réponses biologiques et thérapies alternatives ( U1007 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ), Université Paris Descartes - Paris 5 ( UPD5 )
Jazyk: angličtina
Rok vydání: 2015
Předmět:
0301 basic medicine
Cancer Research
Pathology
[SDV]Life Sciences [q-bio]
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
Neuroblastoma
0302 clinical medicine
[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST]
MYCN
Gene duplication
Neoplasm
Child
Oncogene Proteins
N-Myc Proto-Oncogene Protein
Nuclear Proteins
General Medicine
Articles
Gene Expression Regulation
Neoplastic
Oncology
Differentiation
030220 oncology & carcinogenesis
Child
Preschool
Molecular Medicine
medicine.medical_specialty
Tumor suppressor gene
Adolescent
[SDV.CAN]Life Sciences [q-bio]/Cancer
Disease-Free Survival
03 medical and health sciences
Genetic Heterogeneity
Cell Line
Tumor
Genetics
medicine
Biomarkers
Tumor
Humans
[ MATH.MATH-ST ] Mathematics [math]/Statistics [math.ST]
Ganglioneuroma
WT1 Proteins
neoplasms
[ SDV ] Life Sciences [q-bio]
business.industry
Genetic heterogeneity
Gene Amplification
Infant
Newborn
Infant
medicine.disease
030104 developmental biology
Tumor progression
Cancer research
Wilms' tumors
business
Zdroj: Molecular Oncology
Molecular Oncology, Elsevier, 2016, 10 (2), pp.240-252. ⟨10.1016/j.molonc.2015.09.010⟩
Molecular Oncology, Elsevier, 2016, 10 (2), pp.240-252. 〈https://www.journals.elsevier.com/molecular-oncology〉. 〈10.1016/j.molonc.2015.09.010〉
ISSN: 1574-7891
1878-0261
DOI: 10.1016/j.molonc.2015.09.010⟩
Popis: International audience; Neuroblastoma (NB) is the most common extra cranial solid tumor in childhood and the most frequently diagnosed neoplasm during infancy. A striking feature of this tumor is its clinical heterogeneity. Several tumor progression markers have been delineated so far, among which MYCN amplification, which occurs in about 25% of total NB cases, with the percentage increasing to 30% in advanced stage NB. Although MYCN amplification is strongly correlated with NB of poor outcome, the MYCN status cannot alone predict all cases of poor survival in NB. Indeed NB without MYCN amplification (about 70–80% of NB) are not always favorable. WT1 was initially identified as a tumor suppressor gene involved in the development of a pediatric renal tumor (Wilms' tumor). Here, we describe an inverse correlation between WT1 expression and MYCN amplification and expression. However and most notably, our results show that WT1 gene expression is associated with a poor outcome for patients showing non-MYCN-amplified tumors. Thus WT1 expression is clinically significant in NB and may be a prognostic marker for better risk stratification and for an optimized therapeutic management of NB.
Databáze: OpenAIRE
Externí odkaz: