Posterior vitreous detachment in absentia

Autor: Maranian, Mel J, Snead, Martin P
Přispěvatelé: Snead, Martin P [0000-0003-0042-8659], Apollo - University of Cambridge Repository
Rok vydání: 2022
Předmět:
Zdroj: Eye. 37:388-390
ISSN: 1476-5454
0950-222X
DOI: 10.1038/s41433-022-02248-3
Popis: The relationship between the vitreous body, posterior vitreous detachment (PVD) and retina has been the focus of much research for over a hundred years [1-10 and references therein] and yet in spite of such prolonged investigation, there is still much that is not understood, particularly: a) The changes preceding and initiating uncomplicated (or “physiological”) separation of the posterior hyaloid membrane (PHM) from the retina and, b) The pathological variations of this process that influence so many of the vitreoretinal disorders dealt with today and thereby their management. Historically, much has been theorised on the combined biological changes of syneresis and synchisis leading in some ill-defined manner to weakening adhesion at the vitreoretinal interface, inducing the outer vitreous cortex to separate from the inner limiting membrane of the retina. In contrast, more recent research [11-14] has demonstrated that PVD is not simply an inevitable consequence of age related syneresis but more a distinct immunohistochemically confirmed separation of the posterior hyaloid membrane (PHM) from the retinal surface and that separation of this type IV collagen basement membrane can still occur in individuals in whom all cortical gel (syneretic or otherwise) has been previously removed during by vitrectomy surgery.
University of Cambridge Retinal Research Fund
Databáze: OpenAIRE
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