Benefits of Using Stereotactic Body Radiotherapy in Patients With Metachronous Oligometastases of Hormone-Sensitive Prostate Cancer Detected by [18F]fluoromethylcholine PET/CT

Autor: Hein J. Verberne, Maartje Piet, Daniela E. Oprea-Lager, R. Jeroen A. van Moorselaar, Joyce M. van Dodewaard-de Jong, Otto S. Hoekstra, Henk M.W. Verheul, Max Dahele, Matthijs C.F. Cysouw, Alfons J.M. van den Eertwegh, Adriaan D. Bins, Esther W. Bouman-Wammes, Ben J. Slotman
Přispěvatelé: Medical oncology, CCA - Cancer Treatment and quality of life, Radiation Oncology, Radiology and nuclear medicine, Urology, ACS - Heart failure & arrhythmias, Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Nuclear Medicine, CCA - Cancer Treatment and Quality of Life, Oncology
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Bouman-Wammes, E W, van Dodewaard-De Jong, J M, Dahele, M, Cysouw, M C F, Hoekstra, O S, van Moorselaar, R J A, Piet, M A H, Verberne, H J, Bins, A D, Verheul, H M W, Slotman, B J, Oprea-Lager, D E & Van den Eertwegh, A J M 2017, ' Benefits of Using Stereotactic Body Radiotherapy in Patients With Metachronous Oligometastases of Hormone-Sensitive Prostate Cancer Detected by [18F]fluoromethylcholine PET/CT ', Clinical Genitourinary Cancer, vol. 15, no. 5, pp. e773-e782 . https://doi.org/10.1016/j.clgc.2017.03.009
Clinical Genitourinary Cancer, 15(5), e773-e782. Elsevier
Clinical genitourinary cancer, 15(5), E773-E782. Elsevier
ISSN: 1558-7673
DOI: 10.1016/j.clgc.2017.03.009
Popis: Stereotactic body radiation therapy (SBRT) might postpone the start of androgen deprivation therapy (ADT) in patients with oligometastatic recurrence of hormone-sensitive prostate cancer. We included 43 SBRT-treated patients, and a control cohort of 20 non–SBRT-treated patients, in this retrospective study. Patients in the SBRT cohort could start ADT significantly later, and the time till castration resistance was significantly longer. Introduction For patients with oligometastatic recurrence of prostate cancer (PC), stereotactic body radiation therapy (SBRT) represents an attractive treatment option, as it is safe without major side effects. The aim of this study was to investigate the impact of SBRT in delaying the start of androgen deprivation therapy (ADT). Patients and Methods Forty-three patients treated with SBRT for oligometastatic recurrence (< 5 metastases) of hormone-sensitive PC, defined with [18F]fluoromethylcholine positron emission tomography/computed tomography were included. As a control group, 20 patients with oligometastatic disease not treated with SBRT were identified from another hospital. Data were collected retrospectively. Results A post-SBRT prostate-specific antigen (PSA) response was seen in 29 (67.4%) of 43 patients. Median ADT–free survival (ADT-FS) was 15.6 months (95% confidence interval [CI], 11.7-19.5) for the whole group, and 25.7 months (95% CI, 9.0-42.4) for patients with a PSA response. Seven patients were treated with a second course of SBRT because of oligometastatic disease recurrence; the ADT-FS in this group was 32.1 months (95% CI, 7.8-56.5). Compared with the control group, the ADT-FS from first diagnosis of metastasis was significantly longer, with 17.3 (95% CI, 13.7-20.9) months versus 4.19 months (95% CI, 0.0-9.0), P < .001. Also, time between diagnosis of the metastasis until progression of disease during ADT use (castration resistance) was longer for the SBRT-treated patients (mean 66.6, 95% CI, 53.5-79.8, vs. 36.41, 95% CI, 26.0-46.8 months, P = .020). There were no grade III or IV adverse events reported. Conclusion SBRT can safely and effectively be used to postpone ADT in appropriately selected patients with oligometastatic recurrence of PC.
Databáze: OpenAIRE
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