Pregnancy outcomes after maternal betahistine exposure: A case series
| Autor: | Cuneyt Kemal Buharalioglu, Yusuf Cem Kaplan, Selin Acar, Hilal Erol-Coskun, Baris Karadas, Gözde Küçüksolak, Tijen Kaya-Temiz |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Turkey Toxicology Miscarriage Histamine Agonists Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Epidemiology medicine Humans Betahistine 030212 general & internal medicine Pregnancy outcomes Maternal-Fetal Exchange Obstetrics business.industry Pregnancy Outcome Abnormalities Drug-Induced Middle Aged medicine.disease Teratology Sample size determination Female business Risk assessment 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Reproductive Toxicology. 79:79-83 |
| ISSN: | 0890-6238 |
| Popis: | Objective To investigate the pregnancy outcomes of women who were exposed to betahistine during their pregnancies. Methods We identified and evaluated the outcomes of 27 pregnant women who were referred to Terafar (Teratology Information Service, Izmir, Turkey) for a teratological risk assessment. Results Of 24 pregnancies with known outcomes, 21 resulted in live births (including two pairs of twins) whereas two ended with miscarriage and three with elective terminations. Among the 20 live births for whom the malformation details were available, there were 17 normal outcomes, one major and two minor congenital malformations. Conclusions Despite a number of limitations, this case series may be of value regarding counseling pregnant women with inadvertent betahistine exposure. Further epidemiological studies with larger sample sizes and control groups are necessary to draw more definite conclusions. |
| Databáze: | OpenAIRE |
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