Prognostic performance of pre-treatment NLR and PLR in patients suffering from osteosarcoma
| Autor: | Jun Su, Zhi Li Liu, Wen Kai Xia, Qing Feng Lin, Dong Shen, Wei Dong Mao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Blood Platelets Male 0301 basic medicine Oncology medicine.medical_specialty Neutrophils PLR Bone Neoplasms Adenocarcinoma Preoperative care NLR Young Adult 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine Preoperative Care Biomarkers Tumor medicine Humans Lymphocytes Survival rate Aged Neoplasm Staging Retrospective Studies Osteosarcoma Receiver operating characteristic business.industry Research fungi Retrospective cohort study Middle Aged Nomogram Prognosis medicine.disease Surgery Survival Rate body regions 030104 developmental biology Lymphatic Metastasis 030220 oncology & carcinogenesis Female business Follow-Up Studies |
| Zdroj: | World Journal of Surgical Oncology |
| ISSN: | 1477-7819 |
| DOI: | 10.1186/s12957-016-0889-2 |
| Popis: | Background Inflammatory response markers have been proposed to predict the clinical outcomes in various cancers. The aim of this study was to explore the influence of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on the prognosis of osteosarcoma. Methods Three hundred fifty-nine patients who underwent curative surgery for osteosarcoma were enrolled from 2005 to 2010. NLR and PLR were calculated from peripheral blood cell counts taken at pre-treatment. Optimal cutoff values of NLR and PLR were determined on the basis of receiver operating characteristic curve analysis. A predictive model was established to predict the clinical outcome for overall survival, and the predictive accuracy of this model was determined by concordance index (c-index). Results Our results showed that advanced stage and metastasis at diagnosis were significantly associated with the high NLR and PLR groups. NLR was an independent prognostic indicator for overall survival (HR = 1.80, 95 % CI = 1.35–2.41, P |
| Databáze: | OpenAIRE |
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