Soluble HLA-G: A novel marker in acute myeloid leukemia patients
| Autor: | Mohamed Abd El Rahman, Nahla Abdel Moneim Hamed, Nabil A El Halawani, Dalia A. Nafea, Ahmed Kasber |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment HLA-G lcsh:Medicine Human leukocyte antigen Immune system AML hemic and lymphatic diseases Internal medicine Medicine bone marrow blasts Chemotherapy business.industry lcsh:R Immune escape Myeloid leukemia General Medicine relapsed Soluble hla medicine.anatomical_structure prognosis Bone marrow newly diagnosed business |
| Zdroj: | Acta Medica International, Vol 4, Iss 1, Pp 51-55 (2017) |
| ISSN: | 2349-0578 |
| DOI: | 10.5530/ami.2017.4.10 |
| Popis: | Objective: to study soluble HLA-G (sHLA-G) in Egyptian acute myeloid leukemia (AML) patients. HLA-G is speculated to be a tumor-driven immune escape mechanism. In addition, it might be a promising target for future immune therapeutic approaches. Methods: Thirty AML patients and 15 healthy controls of matched age and sex were the subject of the study. sHLA-G was done to all patients and controls by ELISA. Results: Statistically significant increase in sHLA-G level was present in AML patients compared to controls, being higher in relapsed cases. HLA-G levels was correlated to bone marrow blast percentages but not affected by age, gender, WBCs or response to chemotherapy. HLA-G had a sensitivity of 100% and a specificity of 62% to detect AML cases. Conclusion: HLA-G may be an additional marker for AML especially relapsed cases |
| Databáze: | OpenAIRE |
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