Comparison of hepatitis B viral loads and viral antigen levels in child-bearing age women with and without pregnancy
| Autor: | Tingmei Chen, Yali Hu, Chenyu Xu, Jingli Liu, Jie Chen, Lanhua Liu, Biao Xu, Yongchun Bi, Yi-Hua Zhou, Biyun Xu |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
China Hepatitis B virus HBsAg Expression of HBsAg and HBeAg Physiology Viral antigen Virus Replication medicine.disease_cause lcsh:Gynecology and obstetrics 03 medical and health sciences 0302 clinical medicine Immune system Pregnancy Outcome Assessment Health Care Humans Medicine Hepatitis B e Antigens 030212 general & internal medicine Pregnancy Complications Infectious lcsh:RG1-991 Fetus Hepatitis B Surface Antigens business.industry Postpartum Period HBV replication virus diseases Obstetrics and Gynecology Viral Load Hepatitis B medicine.disease digestive system diseases Parity Titer HBeAg DNA Viral Female 030211 gastroenterology & hepatology business Research Article |
| Zdroj: | BMC Pregnancy and Childbirth BMC Pregnancy and Childbirth, Vol 18, Iss 1, Pp 1-7 (2018) |
| ISSN: | 1471-2393 |
| DOI: | 10.1186/s12884-018-1932-9 |
| Popis: | Background Pregnancy is a unique physiological condition with the cellular immune functions compromised at some extents to allow the mature of growing fetus. Whether pregnancy may influence the replication of hepatitis B virus (HBV) is less studied. The present study aimed to investigate the influence of pregnancy on the replication of HBV and expression of viral antigens by comparing the levels of HBV DNA and viral antigens in pregnant and non-pregnant women. Methods A total of 727 HBsAg-positive serum samples, collected from 214 pregnant women and 513 non-pregnant women of childbearing age, were included. Based on the pregnancy status, subjects were divided into four groups: nulliparous (n = 158), pregnant (n = 214), 7–12 months postpartum (n = 170), and 2–5 years postpartum (n = 185). The levels of hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) were quantitatively measured with microparticle enzyme immunoassay. HBV DNA levels were detected by fluorescent real-time PCR. Results The median ages of four groups were 25.0, 25.3, 26.2 and 29.3 years, respectively (p |
| Databáze: | OpenAIRE |
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