Desipramine Induces Cardiac Beta-Adrenergic Sensitivity Decrease in Major Depressed Patients without Relationship to Therapeutic Response
| Autor: | G. Allers, A. Puech, D. Blum, S. Vandel, B. Vandel, Gilles Bertschy |
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| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Adrenergic receptor medicine.medical_treatment Down-Regulation Basal (phylogenetics) Heart Rate Internal medicine Desipramine Receptors Adrenergic beta Heart rate medicine Humans Pharmacology (medical) Receptor Depressive Disorder Chemotherapy business.industry Isoproterenol Heart General Medicine Plasma levels Hospitalization Psychiatry and Mental health Endocrinology Mechanism of action medicine.symptom business medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1439-0795 0176-3679 |
| DOI: | 10.1055/s-2007-1014520 |
| Popis: | Nineteen major depressed inpatients were treated over three weeks with desipramine. Cardiac beta-adrenergic receptor sensitivity was evaluated by an isoproterenol test before and after the three-week treatment. Desipramine induced a beta-adrenergic sensitivity decrease in most of the patients: I 20 (isoproterenol dose necessary to increase by 20 beats/min. the basal heart rate) before treatment: 89 +/- 37 ng/kg (mean +/- SD); after treatment: 170 +/- 135 ng/kg; p(t) less than 0.03. Despite a linear relationship between pretreatment beta-adrenergic sensitivity and post-treatment clinical state, there was no relation between post-treatment cardiac beta-adrenergic sensitivity and therapeutic response or even desipramine plasma levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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