Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy

Autor: C Shivaprasad, Amit Goel, Anish Kolly, Sridevi Atluri, H A Vijaya Sarathi
Rok vydání: 2017
Předmět:
Male
Diabetic neuropathy
lcsh:Medicine
Type 2 diabetes
Biochemistry
Endocrinology
Nerve Fibers
0302 clinical medicine
Diabetic Neuropathies
Animal Cells
Sensory threshold
Odds Ratio
Medicine and Health Sciences
Diabetes diagnosis and management
Electrochemistry
030212 general & internal medicine
lcsh:Science
Musculoskeletal System
Neurons
Multidisciplinary
Physics
Classical Mechanics
Galvanic Skin Response
Middle Aged
Chemistry
Neurology
Sensory Thresholds
embryonic structures
Physical Sciences
Legs
Female
Anatomy
Cellular Types
Research Article
medicine.medical_specialty
HbA1c
Endocrine Disorders
Urology
030209 endocrinology & metabolism
Vibration
03 medical and health sciences
Vibration perception
Diabetes mellitus
Confidence Intervals
Diabetes Mellitus
medicine
Humans
Hemoglobin
Peripheral Neuropathy
business.industry
lcsh:R
Limbs (Anatomy)
Biology and Life Sciences
Proteins
Cell Biology
medicine.disease
Diagnostic medicine
Confidence interval
Neuropathy
Surgery
Peripheral neuropathy
ROC Curve
Metabolic Disorders
Cellular Neuroscience
lcsh:Q
Perception
Feet (Anatomy)
Skin conductance
business
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0183973 (2017)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0183973
Popis: The early diagnosis of diabetic peripheral neuropathy (DPN) is challenging. Sudomotor dysfunction is one of the earliest detectable abnormalities in DPN. The present study aimed to determine the diagnostic performance of the electrochemical skin conductance (ESC) test in detecting early DPN, compared with the vibration perception threshold (VPT) test and diabetic neuropathy symptom (DNS) score, using the modified neuropathy disability score (NDS) as the reference standard. Five hundred and twenty-three patients with type 2 diabetes underwent an NDS-based clinical assessment for neuropathy. Participants were classified into the DPN and non-DPN groups based on the NDS (≥ 6). Both groups were evaluated further using the DNS, and VPT and ESC testing. A receiver-operator characteristic (ROC) curve analysis was performed to compare the efficacy of ESC measurements with those of DNS and VPT testing in detecting DPN. The DPN group (n = 110, 21%) had significantly higher HbA1c levels and longer diabetes durations compared with the non-DPN group (n = 413). The sensitivity of feet ESC < 60 μS, VPT testing, and DNS in detecting DPN were 85%, 72%, and 52%, respectively. The specificity of feet ESC, VPT, and DNS in detecting DPN were 85%, 90% and 60% respectively. The areas under the curves of the ROC plots for feet ESC, VPT testing, and DNS were 0.88, 0.84, and 0.6, respectively. A significant inverse linear relationship was noted between VPT and feet ESC (r = -0.45, p = 15 V, and DNS ≥ 1, were 16.4, 10.9 and 1.8, respectively. ESC measurement is an objective and sensitive technique for the early detection of DPN. Feet ESC measurement was superior to VPT testing for identifying patients with early DPN.
Databáze: OpenAIRE
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