Molecular Pathology of Lung Tumors
| Autor: | Helmut Popper |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
Cisplatin medicine.medical_specialty Lung biology Molecular pathology Adenoid cystic carcinoma business.industry medicine.medical_treatment medicine.disease respiratory tract diseases Targeted therapy Metastasis medicine.anatomical_structure Internal medicine Carcinoma medicine biology.protein Epidermal growth factor receptor business medicine.drug |
| Zdroj: | Pathology of Lung Disease ISBN: 9783662504895 Pathology of Lung Disease ISBN: 9783030557423 |
| Popis: | Within the last decade, many important discoveries were made in the regulation of growth, differentiation, apoptosis, and metastasis of lung cancers. These findings have dramatically changed the “ignorance” in the oncology community about the classification of lung carcinomas. A decade ago, oncologists were mainly interested to get the differentiation between small cell (SCLC) and non-small cell carcinomas (NSCLC) of the lung. With the findings of different responses for cisplatin and anti-angiogenic treatment in adenocarcinomas versus squamous cell carcinomas, this simple clinical lung carcinoma classification schema was abolished. Now oncologists want to know the differentiation within NSCLC, and the near future will even increase subtyping of the different NSCLC entities. In this review, we will first focus on general aspects of molecular pathology in lung carcinomas and then discuss different genetic abnormalities within the different entities. These abnormalities will be ordered according to their importance such as targeted therapy and impact on outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|