Metabolic changes in rats fed a low protein diet during post-weaning growth
| Autor: | S. Claeyssens, A. Lavoinne, Brigitte Bois-Joyeux, Marc Chanez, Jean Peret, M. Fresel-Ragot |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Growth Weaning Biology Fatty Acids Nonesterified Weight Gain Glucagon chemistry.chemical_compound Endocrinology Low-protein diet Internal medicine medicine Animals Insulin Urea Triglycerides Lactalbumin chemistry.chemical_classification Glycogen Fatty acid Rats Inbred Strains Blood Proteins Organ Size Rats chemistry Liver Triiodothyronine Dietary Proteins Phosphoenolpyruvate carboxykinase Energy Intake Oxidation-Reduction Pyruvate kinase |
| Zdroj: | Metabolism: clinical and experimental. 39(7) |
| ISSN: | 0026-0495 |
| Popis: | Metabolic changes in rats fed a low protein diet were investigated during 3 weeks after weaning using lactalbumin (LP) as dietary protein source. The energy intake was higher and the weight gain lower in rats fed the low protein diet (6%, LP group) than in control rats (13% lactalbumin, C group). Low protein diet induced no changes in plasma glucose, free fatty acids, or triacylglycerol concentrations; however, plasma protein and urea concentrations were lower in LP than in C rats. Plasma free T3 was higher in LP than in C rats (+38%, day 21) and insulin progressively decreased during the experimental period (-56%, day 21) without change in glucagon. Liver glycogen and triacylglycerol concentrations (+40% and +180%, respectively, day 21), and cytosolic and mitochondrial redox states increased (+100% and +100%, day 21), and protein concentration was decreased (-15%, day 21). Pyruvate kinase (PK) and malic enzyme activities were higher in LP than in C rats throughout the experiment (+80% and +210%, respectively, day 21), and glucose-6-phosphate dehydrogenase (G6PDH) activity progressively decreased (-65%, day 21). Phosphoenolpyruvate carboxykinase (PEPCK) activity increased after 2 weeks on a LP diet (+35%, day 21) and fatty acid synthetase (FAS) activity increased only during the first week on the diet (+100%, day 7). Such hormonal and metabolic changes appeared to be associated with the development of a futile energy-wasting cycle between pyruvate and phosphoenolpyruvate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|