An assessment of the malignant potential of actinic keratoses and Bowen's disease: p53 and PCNA expression pattern correlate with the number of desmosomes
| Autor: | Motoyoshi Maruno, Hiroshi Uezato, Saeef Taher Ramzi, Noor Mohammad Khaskhely, Shigeo Nonaka, Mohammed Abul Kasem Khan, Atsushi Takamiyagi |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Pathology medicine.medical_specialty Skin Neoplasms Keratosis Bowen's Disease Dermatology Sensitivity and Specificity Reference Values Proliferating Cell Nuclear Antigen Biopsy Carcinoma medicine Biomarkers Tumor Humans Aged Probability Aged 80 and over Bowen's disease biology medicine.diagnostic_test Pcna expression Biopsy Needle General Medicine Actinic keratoses Desmosomes Middle Aged medicine.disease Immunohistochemistry Proliferating cell nuclear antigen Microscopy Electron biology.protein Carcinoma Squamous Cell Female Tumor Suppressor Protein p53 Precancerous Conditions |
| Zdroj: | The Journal of dermatology. 29(9) |
| ISSN: | 0385-2407 |
| Popis: | Actinic keratoses (AK) and Bowen's disease (BD), both intraepidermal skin tumors, have a potential progression to squamous cell carcinoma (SCC). To evaluate the malignant potential of AK and BD, the expression pattern of p53 protein and proliferating cell nuclear antigen (PCNA) were examined in five types of AK and BD by immunohistochemistry. The ultrastructural difference of epidermal cells between AK and BD lesions was investigated. In the study of p53 and PCNA expression, the atrophic and acantholytic types of AK showed lower positive rates compared to others. These two types did not demonstrate all layers expression pattern. The number of desmosomes of the epidermal cells was significantly reduced in BD, and in the bowenoid and hypertrophic types of AK compared with other types of AK The number of hemi-desmosomes showed greatest reduction in BD and the bowenoid type of AK On the basis of our findings, it is hypothesized that atrophic and acantholytic types of AK may have the lowest, and the bowenoid type of AK and BD may have the highest, malignant potential. |
| Databáze: | OpenAIRE |
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