Effectiveness of a human monoclonal anti-endotoxin antibody (HA-1A) in gram-negative sepsis: relationship to endotoxin and cytokine levels
| Autor: | C. R. Smith, Isabel E. Allen, M. J. Lubbers, C. H. Wortel, S. J. H. Van Deventer, C. L. Sprung, M. Jastremski, J W ten Cate, M. A. M. Van Der Möhlen |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 1992 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Bacteremia Placebo Antibodies Monoclonal Humanized Gastroenterology Sepsis Internal medicine medicine Immunology and Allergy Humans Interleukin 6 Aged Chemotherapy biology business.industry Interleukin-6 Tumor Necrosis Factor-alpha Antibodies Monoclonal Middle Aged medicine.disease Endotoxins Infectious Diseases Cytokine Immunoglobulin M Immunology Monoclonal biology.protein Cytokines Tumor necrosis factor alpha Antibody business Gram-Negative Bacterial Infections |
| Zdroj: | Journal of infectious diseases, 166(6), 1367-1374. Oxford University Press |
| ISSN: | 0022-1899 |
| Popis: | Gram-negative sepsis is caused by endotoxin-induced release of tumor necrosis factor (TNF) and other cytokines. HA-1A is a human monoclonal antibody that binds specifically to endotoxin. HA-1A should prevent death in endotoxemic patients and reduce serum levels of TNF and interleukin-6 (IL-6). This hypothesis was tested in 82 septic patients who were randomly allocated to receive a single intravenous 100-mg dose of HA-1A or placebo. Pretreatment endotoxemia was detected in 27 patients (33%). Death occurred within 28 days of treatment in 8 (73%) of 11 placebo recipients and in 5 (31%) of 16 HA-1A recipients (P = .02). The median decrease in serum TNF level 24 h after treatment was 12 ng/L in patients given HA-1A and 0 ng/L in placebo recipients (n = 65; P = .04). For IL-6, this was 204 ng/L in patients given HA-1A and 44 ng/L in placebo recipients (n = 67; P = .4). Thus, HA-1A reduces mortality in septic patients with endotoxemia and lowers serum TNF levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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