Neurodevelopmental outcome at 2 years of age in preterm infants with late-onset sepsis
| Autor: | Inge A. Zonnenberg, F. A. M. van den Dungen, E. M. van Dijk-Lokkart, M.M. van Weissenbruch, R. J. Vermeulen |
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| Přispěvatelé: | Pediatric surgery, Medical psychology, Amsterdam Reproduction & Development (AR&D), AII - Infectious diseases, ACS - Diabetes & metabolism, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Infant Premature Diseases Neuropsychological Tests Sepsis late-onset sepsis medicine Humans neonatal infection Prospective Studies Prospective cohort study Psychomotor learning Neurodevelopmental outcome Late onset sepsis business.industry Infant Newborn Gestational age Cognition Prognosis medicine.disease Language development Neurodevelopmental Disorders Child Preschool Pediatrics Perinatology and Child Health Cohort Preterm infant Female business Infant Premature Follow-Up Studies |
| Zdroj: | European Journal of Pediatrics, 178(5), 673-680. Springer Verlag Zonnenberg, I A, van Dijk-Lokkart, E M, van den Dungen, F A M, Vermeulen, R J & van Weissenbruch, M M 2019, ' Neurodevelopmental outcome at 2 years of age in preterm infants with late-onset sepsis ', European Journal of Pediatrics, vol. 178, no. 5, pp. 673-680 . https://doi.org/10.1007/s00431-019-03339-2 European Journal of Pediatrics, 178(5), 673-680. Springer, Cham |
| ISSN: | 0340-6199 |
| DOI: | 10.1007/s00431-019-03339-2 |
| Popis: | Late-onset sepsis is associated with impaired neurodevelopmental outcome in preterm infants. This prospective cohort study aims to establish the effect of sepsis after 72 h of life on cognitive, psychomotor, and language development of preterm infants (below 32 weeks gestational age and/or below 1500 g). At 2 years corrected age, neurodevelopmental outcome was tested using Bayley's Scales of Infant Development-II, Lexilijst (lexical development questionnaire), and behavior checklists. Of 117 patients included, 85 experienced blood culture-proven infection. Coagulase-negative staphylococci were responsible for 55% of the episodes. No significant differences were found in cognitive, motor, and behavioral scores or lexiquotient comparing patients with versus no proven infection. When comparing three groups (coagulase-negative staphylococci, other, and negative blood culture), a significant difference was found in composite cognitive scores (p = 0.016), in favor of the coagulase-negative staphylococci group versus other causal agent group (p = 0.007). No significant differences were found in other subscales.Conclusion: In this cohort, no differences were found in neurodevelopmental outcome at 2 years corrected age between proven and no proven infection groups; confirmation in larger cohorts with a control group is needed. Patients encountering coagulase-negative staphylococci sepsis showed a significant better cognitive outcome compared to other causal agents. What is Known: • Late-onset sepsis is associated with impaired neurodevelopmental outcome in preterm infants. What is New: • Preterm infants encountering late-onset sepsis by coagulase-negative staphylococci show a better cognitive outcome in comparison to other causal infectious agents in this cohort. • No differences were found in neurodevelopment at 2 years of age in preterm infants with suspected lateonset sepsis, between proven and no proven infection groups. Confirmation is needed in larger cohorts with a substantial control group. |
| Databáze: | OpenAIRE |
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